Antioxidant, mitogenic and immunomodulatory potentials of acacia honey

Muhammad Aliyu, Oyeronke A. Odunola, Ahsana D. Farooq, Osman Mesaik Mohammed Ahmed Hassan, Muhammad I. Choudhary, Mudassar Azhar, Muhammad M. Asif, Ochuko L. Erukainure

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Introduction: This study was primarily designed to investigate the antioxidant, immunomodulatory and mitogenic properties of acacia honey. Materials and Methods: The antioxidant and immunomodulatory potential was evaluated by luminoland lucigenin-amplified chemiluminescence assays, whereas the mitogenic potential was evaluated using cytochalasin B-blocked micronucleus and mitotic index assays in vitro from whole blood, neutrophils, macrophages and peripheral lymphocytes. Superoxide anion and DPPH radical scavenging activity as well as reducing power were evaluated to further underscore the antioxidant property of acacia honey. Results: Dose-dependent (p50s of 0.75%, 0.2%, and 0.24% and 50 of 1.58%) and superoxide anion (IC50 of 2.15%) radicals. The reducing power of honey increased with increasing concentrations. Conclusions: Our study demonstrates the antioxidant, mitogenic and immunomodulatory properties of acacia honey.

Original languageEnglish
Pages (from-to)68-78
Number of pages11
JournalNutritional Therapy and Metabolism
Volume32
Issue number2
DOIs
Publication statusPublished - 2014
Externally publishedYes

Fingerprint

Acacia
Honey
Antioxidants
Superoxides
Cytochalasin B
Mitotic Index
Luminescence
Inhibitory Concentration 50
Neutrophils
Macrophages
Lymphocytes

Keywords

  • Acacia honey
  • Chemiluminescence assay
  • Cytochalasin B-blocked micronucleus assay
  • Genotoxicity
  • Mitotic index assay

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine
  • Nutrition and Dietetics

Cite this

Aliyu, M., Odunola, O. A., Farooq, A. D., Mohammed Ahmed Hassan, O. M., Choudhary, M. I., Azhar, M., ... Erukainure, O. L. (2014). Antioxidant, mitogenic and immunomodulatory potentials of acacia honey. Nutritional Therapy and Metabolism, 32(2), 68-78. https://doi.org/10.5301/NTM.2014.12285

Antioxidant, mitogenic and immunomodulatory potentials of acacia honey. / Aliyu, Muhammad; Odunola, Oyeronke A.; Farooq, Ahsana D.; Mohammed Ahmed Hassan, Osman Mesaik; Choudhary, Muhammad I.; Azhar, Mudassar; Asif, Muhammad M.; Erukainure, Ochuko L.

In: Nutritional Therapy and Metabolism, Vol. 32, No. 2, 2014, p. 68-78.

Research output: Contribution to journalArticle

Aliyu, M, Odunola, OA, Farooq, AD, Mohammed Ahmed Hassan, OM, Choudhary, MI, Azhar, M, Asif, MM & Erukainure, OL 2014, 'Antioxidant, mitogenic and immunomodulatory potentials of acacia honey', Nutritional Therapy and Metabolism, vol. 32, no. 2, pp. 68-78. https://doi.org/10.5301/NTM.2014.12285
Aliyu M, Odunola OA, Farooq AD, Mohammed Ahmed Hassan OM, Choudhary MI, Azhar M et al. Antioxidant, mitogenic and immunomodulatory potentials of acacia honey. Nutritional Therapy and Metabolism. 2014;32(2):68-78. https://doi.org/10.5301/NTM.2014.12285
Aliyu, Muhammad ; Odunola, Oyeronke A. ; Farooq, Ahsana D. ; Mohammed Ahmed Hassan, Osman Mesaik ; Choudhary, Muhammad I. ; Azhar, Mudassar ; Asif, Muhammad M. ; Erukainure, Ochuko L. / Antioxidant, mitogenic and immunomodulatory potentials of acacia honey. In: Nutritional Therapy and Metabolism. 2014 ; Vol. 32, No. 2. pp. 68-78.
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