Antioxidant, anti-inflammatory and antinociceptive activities of Mitragyna speciosa and Erythroxylum cuneatum

Siti Rohani Saleh, Mizaton Hazizul Hasan, Md Ikram Mohd Said, Mohd Ilham Adenan, Aishah Adam

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Abstract

    This study was conducted to determine the potential of both Mitragyna speciosa (MS) and Erythroxylum cuneatum (EC) aqueous leaves extracts as antioxidant, anti-inflammatory and antinociceptive agents. MS has been used traditionally by local folks to treat diarrhea, reducing cough, alleviate pain and to combat fatigue. Meanwhile, EC was used as fish poison and tonic for miscarriage. MS and EC aqueous leaf extracts have the capability to chelate iron and have potent anti-inflammatory and antinociceptive activities but were not effectively inhibiting the production of uric acid. Both extracts (50, 100, 200 and 400 mg/kg, p.o) were given to rodents in carrageenan-induced rat paw edema model and acetic acid-induced writhing in mice models to study their anti-inflammatory and antinociceptive activities, respectively. Animals given (400 mg/kg, p.o) showed significant (p0.05) reduction in number of writhes and paw edema volume compared to control.

    Original languageEnglish
    Title of host publicationSHUSER 2012 - 2012 IEEE Symposium on Humanities, Science and Engineering Research
    Pages1087-1091
    Number of pages5
    DOIs
    Publication statusPublished - 2012
    Event2012 IEEE Symposium on Humanities, Science and Engineering Research, SHUSER 2012 - Kuala Lumpur
    Duration: 24 Jun 201227 Jun 2012

    Other

    Other2012 IEEE Symposium on Humanities, Science and Engineering Research, SHUSER 2012
    CityKuala Lumpur
    Period24/6/1227/6/12

    Fingerprint

    Antioxidants
    Writhe
    Pain
    Fish
    Acetic acid
    Iron
    Fatigue
    Rats
    Mouse
    Animals
    Leaves
    Fatigue of materials
    Acids
    Model
    Rodentia

    Keywords

    • anti-inflammatory
    • antinociceptive
    • antioxidant
    • Erythroxylum cuneatum
    • Mitragyna speciosa

    ASJC Scopus subject areas

    • Computational Mathematics

    Cite this

    Saleh, S. R., Hasan, M. H., Said, M. I. M., Adenan, M. I., & Adam, A. (2012). Antioxidant, anti-inflammatory and antinociceptive activities of Mitragyna speciosa and Erythroxylum cuneatum. In SHUSER 2012 - 2012 IEEE Symposium on Humanities, Science and Engineering Research (pp. 1087-1091). [6268787] https://doi.org/10.1109/SHUSER.2012.6268787

    Antioxidant, anti-inflammatory and antinociceptive activities of Mitragyna speciosa and Erythroxylum cuneatum. / Saleh, Siti Rohani; Hasan, Mizaton Hazizul; Said, Md Ikram Mohd; Adenan, Mohd Ilham; Adam, Aishah.

    SHUSER 2012 - 2012 IEEE Symposium on Humanities, Science and Engineering Research. 2012. p. 1087-1091 6268787.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Saleh, SR, Hasan, MH, Said, MIM, Adenan, MI & Adam, A 2012, Antioxidant, anti-inflammatory and antinociceptive activities of Mitragyna speciosa and Erythroxylum cuneatum. in SHUSER 2012 - 2012 IEEE Symposium on Humanities, Science and Engineering Research., 6268787, pp. 1087-1091, 2012 IEEE Symposium on Humanities, Science and Engineering Research, SHUSER 2012, Kuala Lumpur, 24/6/12. https://doi.org/10.1109/SHUSER.2012.6268787
    Saleh SR, Hasan MH, Said MIM, Adenan MI, Adam A. Antioxidant, anti-inflammatory and antinociceptive activities of Mitragyna speciosa and Erythroxylum cuneatum. In SHUSER 2012 - 2012 IEEE Symposium on Humanities, Science and Engineering Research. 2012. p. 1087-1091. 6268787 https://doi.org/10.1109/SHUSER.2012.6268787
    Saleh, Siti Rohani ; Hasan, Mizaton Hazizul ; Said, Md Ikram Mohd ; Adenan, Mohd Ilham ; Adam, Aishah. / Antioxidant, anti-inflammatory and antinociceptive activities of Mitragyna speciosa and Erythroxylum cuneatum. SHUSER 2012 - 2012 IEEE Symposium on Humanities, Science and Engineering Research. 2012. pp. 1087-1091
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