Antioxidant and antimicrobial activities of novel quinazolinones

Ahmed A. Al-Amiery, Abdul Amir H. Kadhum, Mohammed Shamel, Mustafa Satar, Yehiah Khalid, Abu Bakar Mohamad

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

The antimicrobial and antioxidant activities of quinazolinones have widely been studied. However, there have been no studies on the antimicrobial and antioxidant activities of synthetic quinazolinones derived from anthranilic acid. The antimicrobial activities of newly synthesized compounds against a number of medically relevant bacteria and fungi were investigated. In addition, the free-radical scavenging activities of these compounds were measured using the 1,1-diphenyl-2-picrylhydrazyl, hydroxyl, and nitroxyl radical assays and were compared with the activity of ascorbic acid. All compounds exhibited significant antimicrobial activity. In addition, these compounds were found to be superior to ascorbic acid in terms of their antioxidant activities. Theoretical calculations of the synthesized compounds were performed using molecular structures with optimized geometries. The molecular orbital calculations provide a detailed description of the orbitals, including the spatial characteristics, nodal patterns, and the contributions of individual atoms. The energies of the highest occupied molecular orbital and the lowest unoccupied molecular orbital and the structures of the compounds are shown.

Original languageEnglish
Pages (from-to)236-242
Number of pages7
JournalMedicinal Chemistry Research
Volume23
Issue number1
DOIs
Publication statusPublished - Jan 2014

Fingerprint

Quinazolinones
Molecular orbitals
Antioxidants
Molecular Structure
Ascorbic Acid
Orbital calculations
Scavenging
Fungi
Hydroxyl Radical
Molecular structure
Free Radicals
Assays
Bacteria
Atoms
Geometry

Keywords

  • Antioxidant
  • Ciprofloxacin
  • Fluconazole
  • Quinazolinones
  • Scavenging
  • Schiff bases

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Organic Chemistry

Cite this

Al-Amiery, A. A., Kadhum, A. A. H., Shamel, M., Satar, M., Khalid, Y., & Mohamad, A. B. (2014). Antioxidant and antimicrobial activities of novel quinazolinones. Medicinal Chemistry Research, 23(1), 236-242. https://doi.org/10.1007/s00044-013-0625-1

Antioxidant and antimicrobial activities of novel quinazolinones. / Al-Amiery, Ahmed A.; Kadhum, Abdul Amir H.; Shamel, Mohammed; Satar, Mustafa; Khalid, Yehiah; Mohamad, Abu Bakar.

In: Medicinal Chemistry Research, Vol. 23, No. 1, 01.2014, p. 236-242.

Research output: Contribution to journalArticle

Al-Amiery, AA, Kadhum, AAH, Shamel, M, Satar, M, Khalid, Y & Mohamad, AB 2014, 'Antioxidant and antimicrobial activities of novel quinazolinones', Medicinal Chemistry Research, vol. 23, no. 1, pp. 236-242. https://doi.org/10.1007/s00044-013-0625-1
Al-Amiery AA, Kadhum AAH, Shamel M, Satar M, Khalid Y, Mohamad AB. Antioxidant and antimicrobial activities of novel quinazolinones. Medicinal Chemistry Research. 2014 Jan;23(1):236-242. https://doi.org/10.1007/s00044-013-0625-1
Al-Amiery, Ahmed A. ; Kadhum, Abdul Amir H. ; Shamel, Mohammed ; Satar, Mustafa ; Khalid, Yehiah ; Mohamad, Abu Bakar. / Antioxidant and antimicrobial activities of novel quinazolinones. In: Medicinal Chemistry Research. 2014 ; Vol. 23, No. 1. pp. 236-242.
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