Antioxidant and antidiabetic effects of flavonoids

A structure-activity relationship based study

Murni Nazira Sarian, Qamar Uddin Ahmed, Siti Zaiton Mat So'Ad, Alhassan Muhammad Alhassan, Suganya Murugesu, Vikneswari Perumal, Sharifah Nurul Akilah Syed Mohamad, Alfi Khatib, Jalifah Latip

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

The best described pharmacological property of flavonoids is their capacity to act as potent antioxidant that has been reported to play an important role in the alleviation of diabetes mellitus. Flavonoids biochemical properties are structure dependent; however, they are yet to be thoroughly understood. Hence, the main aim of this work was to investigate the antioxidant and antidiabetic properties of some structurally related flavonoids to identify key positions responsible, their correlation, and the effect of methylation and acetylation on the same properties. Antioxidant potential was evaluated through dot blot, 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging, ABTS+ radical scavenging, ferric reducing antioxidant power (FRAP), and xanthine oxidase inhibitory (XOI) assays. Antidiabetic effect was investigated through α-glucosidase and dipeptidyl peptidase-4 (DPP-4) assays. Results showed that the total number and the configuration of hydroxyl groups played an important role in regulating antioxidant and antidiabetic properties in scavenging DPPH radical, ABTS+ radical, and FRAP assays and improved both α-glucosidase and DPP-4 activities. Presence of C-2-C-3 double bond and C-4 ketonic group are two essential structural features in the bioactivity of flavonoids especially for antidiabetic property. Methylation and acetylation of hydroxyl groups were found to diminish the in vitro antioxidant and antidiabetic properties of the flavonoids.

Original languageEnglish
Article number8386065
JournalBioMed Research International
Volume2017
DOIs
Publication statusPublished - 1 Jan 2017

Fingerprint

Structure-Activity Relationship
Hypoglycemic Agents
Flavonoids
Antioxidants
Scavenging
Glucosidases
Dipeptidyl Peptidase 4
Acetylation
Assays
Methylation
Hydroxyl Radical
Xanthine Oxidase
Medical problems
Bioactivity
Diabetes Mellitus
Pharmacology

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

Cite this

Sarian, M. N., Ahmed, Q. U., Mat So'Ad, S. Z., Alhassan, A. M., Murugesu, S., Perumal, V., ... Latip, J. (2017). Antioxidant and antidiabetic effects of flavonoids: A structure-activity relationship based study. BioMed Research International, 2017, [8386065]. https://doi.org/10.1155/2017/8386065

Antioxidant and antidiabetic effects of flavonoids : A structure-activity relationship based study. / Sarian, Murni Nazira; Ahmed, Qamar Uddin; Mat So'Ad, Siti Zaiton; Alhassan, Alhassan Muhammad; Murugesu, Suganya; Perumal, Vikneswari; Syed Mohamad, Sharifah Nurul Akilah; Khatib, Alfi; Latip, Jalifah.

In: BioMed Research International, Vol. 2017, 8386065, 01.01.2017.

Research output: Contribution to journalArticle

Sarian, MN, Ahmed, QU, Mat So'Ad, SZ, Alhassan, AM, Murugesu, S, Perumal, V, Syed Mohamad, SNA, Khatib, A & Latip, J 2017, 'Antioxidant and antidiabetic effects of flavonoids: A structure-activity relationship based study', BioMed Research International, vol. 2017, 8386065. https://doi.org/10.1155/2017/8386065
Sarian, Murni Nazira ; Ahmed, Qamar Uddin ; Mat So'Ad, Siti Zaiton ; Alhassan, Alhassan Muhammad ; Murugesu, Suganya ; Perumal, Vikneswari ; Syed Mohamad, Sharifah Nurul Akilah ; Khatib, Alfi ; Latip, Jalifah. / Antioxidant and antidiabetic effects of flavonoids : A structure-activity relationship based study. In: BioMed Research International. 2017 ; Vol. 2017.
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