Antinociceptive activity of natural honey in thermal-nociception models in mice

M. Kamran Azim, Humera Perveen, Osman Mesaik Mohammed Ahmed Hassan, Shabana U. Simjee

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Several honey samples of Pakistani origin have been analysed for their effect on nociception. Among the tested samples, Acacia honey showed most effective dose-dependent antinociceptive activity which was significantly different from the untreated group in tail-flick and paw-withdrawal tests (p <0.01 and p <0.003), respectively. The antinociceptive activity of honey reached a maximum at 60 min post-treatment and then gradually decreased, whereas the activity of indomethacin was persistent at 120 min post-treatment. The absence of antinociceptive activity in simulated honey (which contained fructose, glucose, maltose and sucrose representing the major constituents of honey) indicated that the active principle(s) might be present in minor constituents of honey.

Original languageEnglish
Pages (from-to)194-197
Number of pages4
JournalPhytotherapy Research
Volume21
Issue number2
DOIs
Publication statusPublished - Feb 2007
Externally publishedYes

Fingerprint

Nociception
Maltose
Honey
Fructose
Indomethacin
Sucrose
Hot Temperature
Glucose
Acacia
Tail

Keywords

  • Acacia honey
  • Analgesic activity
  • Antinociception
  • Honey
  • Plectranthus honey

ASJC Scopus subject areas

  • Drug Discovery
  • Organic Chemistry
  • Pharmacology

Cite this

Azim, M. K., Perveen, H., Mohammed Ahmed Hassan, O. M., & Simjee, S. U. (2007). Antinociceptive activity of natural honey in thermal-nociception models in mice. Phytotherapy Research, 21(2), 194-197. https://doi.org/10.1002/ptr.2049

Antinociceptive activity of natural honey in thermal-nociception models in mice. / Azim, M. Kamran; Perveen, Humera; Mohammed Ahmed Hassan, Osman Mesaik; Simjee, Shabana U.

In: Phytotherapy Research, Vol. 21, No. 2, 02.2007, p. 194-197.

Research output: Contribution to journalArticle

Azim, MK, Perveen, H, Mohammed Ahmed Hassan, OM & Simjee, SU 2007, 'Antinociceptive activity of natural honey in thermal-nociception models in mice', Phytotherapy Research, vol. 21, no. 2, pp. 194-197. https://doi.org/10.1002/ptr.2049
Azim, M. Kamran ; Perveen, Humera ; Mohammed Ahmed Hassan, Osman Mesaik ; Simjee, Shabana U. / Antinociceptive activity of natural honey in thermal-nociception models in mice. In: Phytotherapy Research. 2007 ; Vol. 21, No. 2. pp. 194-197.
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