Antimicrobial, antioxidant, antitumour-promoting and cytotoxic activities of different plant part extracts of Garcinia atroviridis Griff. ex T. Anders

Muhammad Mukram Mohamed Mackeen, A. M. Ali, N. H. Lajis, K. Kawazu, Z. Hassan, M. Amran, M. Habsah, L. Y. Mooi, S. M. Mohamed

Research output: Contribution to journalArticle

108 Citations (Scopus)

Abstract

Crude extracts (methanol) of various parts, viz. the leaves, fruits, roots, stem and trunk bark, of Garcinia atroviridis were screened for antimicrobial, cytotoxic, brine shrimp toxic, antitumour-promoting and antioxidant activities. The crude extracts exhibited predominantly antibacterial activity with the root extract showing the strongest inhibition against the test bacteria at a minimum inhibitory dose (MID) of 15.6 μg/disc. Although all the extracts failed to inhibit the growth of most of the test fungi, significant antifungal activity against Cladosporium herbarum was exhibited by most notably the fruit (MID: 100 μg), and the leaf (MID: 400 μg) extracts. None of the extracts were significantly cytotoxic, and lethal towards brine shrimps. The root, leaf, trunk and stem bark extracts (except for the fruits) showed strong antioxidant activity exceeding that of the standard antioxidant, α-tocopherol. Antitumour-promoting activity (>95% inhibition) was shown by the fruit, leaf, stem and trunk bark extracts. (C) 2000 Elsevier Science Ireland Ltd.

Original languageEnglish
Pages (from-to)395-402
Number of pages8
JournalJournal of Ethnopharmacology
Volume72
Issue number3
DOIs
Publication statusPublished - Oct 2000
Externally publishedYes

Fingerprint

Garcinia
Plant Extracts
Fruit
Antioxidants
Artemia
Complex Mixtures
Cladosporium
Tocopherols
Poisons
Methanol
Fungi
Bacteria
Growth

Keywords

  • Antimicrobial
  • Antioxidant
  • Antitumour-promoting
  • Garcinia atroviridis

ASJC Scopus subject areas

  • Pharmacology

Cite this

Antimicrobial, antioxidant, antitumour-promoting and cytotoxic activities of different plant part extracts of Garcinia atroviridis Griff. ex T. Anders. / Mohamed Mackeen, Muhammad Mukram; Ali, A. M.; Lajis, N. H.; Kawazu, K.; Hassan, Z.; Amran, M.; Habsah, M.; Mooi, L. Y.; Mohamed, S. M.

In: Journal of Ethnopharmacology, Vol. 72, No. 3, 10.2000, p. 395-402.

Research output: Contribution to journalArticle

Mohamed Mackeen, Muhammad Mukram ; Ali, A. M. ; Lajis, N. H. ; Kawazu, K. ; Hassan, Z. ; Amran, M. ; Habsah, M. ; Mooi, L. Y. ; Mohamed, S. M. / Antimicrobial, antioxidant, antitumour-promoting and cytotoxic activities of different plant part extracts of Garcinia atroviridis Griff. ex T. Anders. In: Journal of Ethnopharmacology. 2000 ; Vol. 72, No. 3. pp. 395-402.
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