Antimicrobial and cytotoxic activities of some Malaysian flowering plants

Jasril, S. M. Mohamed, Muhammad Mukram Mohamed Mackeen, N. H. Lajis, A. A. Rahman, A. M. Ali

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

A total of 43 extracts from 21 species of Malaysian flowering plants were screened for antimicrobial and cytotoxic activities. Antimicrobial activity was tested against fungi, including yeast and candida, as well as Gram-positive and Gram-negative bacteria, and cytotoxicity was assayed using the CEM-SS and HT-29 cell lines. The methanol extracts of the roots and stems of Plumeria acutifolia showed the highest antimicrobial activity, i.e. against Saccharomyces cerevisiae and Candida lipolytica, and mostly moderate activity against the other microbes such as Aspergillus ochraceous and Saccharomyces lipolytica. Phyllanthus emblica also showed moderate activity especially that of the methanol extracts. The methanol extract of the roots of Plumeria acutifolia showed the strongest cytotoxic activity (CD50 = 3 μg/ml). Most of Zingiberaceae species gave negative results for antimicrobial activity and showed low cytotoxic activity.

Original languageEnglish
Pages (from-to)172-176
Number of pages5
JournalNatural Product Sciences
Volume5
Issue number4
Publication statusPublished - 1999
Externally publishedYes

Fingerprint

Apocynaceae
Methanol
Candida
Yeast
Phyllanthus emblica
Zingiberaceae
HT29 Cells
Saccharomyces
Aspergillus
Cytotoxicity
Fungi
Gram-Negative Bacteria
Saccharomyces cerevisiae
Bacteria
Yeasts
Cells
Cell Line

Keywords

  • Antimicrobial
  • Cytotoxicity
  • Plant extracts

ASJC Scopus subject areas

  • Molecular Medicine

Cite this

Jasril, Mohamed, S. M., Mohamed Mackeen, M. M., Lajis, N. H., Rahman, A. A., & Ali, A. M. (1999). Antimicrobial and cytotoxic activities of some Malaysian flowering plants. Natural Product Sciences, 5(4), 172-176.

Antimicrobial and cytotoxic activities of some Malaysian flowering plants. / Jasril; Mohamed, S. M.; Mohamed Mackeen, Muhammad Mukram; Lajis, N. H.; Rahman, A. A.; Ali, A. M.

In: Natural Product Sciences, Vol. 5, No. 4, 1999, p. 172-176.

Research output: Contribution to journalArticle

Jasril, Mohamed, SM, Mohamed Mackeen, MM, Lajis, NH, Rahman, AA & Ali, AM 1999, 'Antimicrobial and cytotoxic activities of some Malaysian flowering plants', Natural Product Sciences, vol. 5, no. 4, pp. 172-176.
Jasril ; Mohamed, S. M. ; Mohamed Mackeen, Muhammad Mukram ; Lajis, N. H. ; Rahman, A. A. ; Ali, A. M. / Antimicrobial and cytotoxic activities of some Malaysian flowering plants. In: Natural Product Sciences. 1999 ; Vol. 5, No. 4. pp. 172-176.
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