Antimicrobial and antioxidant activities of new metal complexes derived from 3-aminocoumarin

Research output: Contribution to journalArticle

63 Citations (Scopus)

Abstract

3-Aminocoumarin (L) has been synthesized and used as a ligand for the formation of Cr(III), Ni(II), and Cu(II) complexes. The chemical structures were characterized using different spectroscopic methods. The elemental analyses revealed that the complexes where M=Ni(II) and Cu(II) have the general formulae [ML 2Cl 2], while the Cr(III) complex has the formula [CrL 2Cl 2]Cl. The molar conductance data reveal that all the metal chelates, except the Cr(III) one, are non-electrolytes. From the magnetic and UV-Visible spectra, it is found that these complexes have octahedral structures. The stability for the prepared complexes was studied theoretically using Density Function Theory. The total energy for the complexes was calculated and it was shown that the copper complex is the most stable one. Complexes were tested against selected types of microbial organisms and showed significant activities. The free radical scavenging activity of metal complexes have been determined by measuring their interaction with the stable free radical DPPH and all the compounds have shown encouraging antioxidant activities.

Original languageEnglish
Pages (from-to)6969-6984
Number of pages16
JournalMolecules
Volume16
Issue number8
DOIs
Publication statusPublished - Aug 2011

Fingerprint

Aminocoumarins
Coordination Complexes
antioxidants
Free Radicals
Antioxidants
free radicals
Scavenging
metals
Probability density function
Copper
Metals
scavenging
Ligands
visible spectrum
organisms
chelates
copper
ligands
interactions
energy

Keywords

  • 3-aminocoumarin
  • Antimicrobial
  • Complexes
  • DPPH
  • Scavenging

ASJC Scopus subject areas

  • Organic Chemistry

Cite this

Antimicrobial and antioxidant activities of new metal complexes derived from 3-aminocoumarin. / Kadhum, Abdul Amir H.; Mohamad, Abu Bakar; Al-Amiery, Ahmed A.; Takriff, Mohd Sobri.

In: Molecules, Vol. 16, No. 8, 08.2011, p. 6969-6984.

Research output: Contribution to journalArticle

@article{8bf861f708bc4b659021c9fb621e0470,
title = "Antimicrobial and antioxidant activities of new metal complexes derived from 3-aminocoumarin",
abstract = "3-Aminocoumarin (L) has been synthesized and used as a ligand for the formation of Cr(III), Ni(II), and Cu(II) complexes. The chemical structures were characterized using different spectroscopic methods. The elemental analyses revealed that the complexes where M=Ni(II) and Cu(II) have the general formulae [ML 2Cl 2], while the Cr(III) complex has the formula [CrL 2Cl 2]Cl. The molar conductance data reveal that all the metal chelates, except the Cr(III) one, are non-electrolytes. From the magnetic and UV-Visible spectra, it is found that these complexes have octahedral structures. The stability for the prepared complexes was studied theoretically using Density Function Theory. The total energy for the complexes was calculated and it was shown that the copper complex is the most stable one. Complexes were tested against selected types of microbial organisms and showed significant activities. The free radical scavenging activity of metal complexes have been determined by measuring their interaction with the stable free radical DPPH and all the compounds have shown encouraging antioxidant activities.",
keywords = "3-aminocoumarin, Antimicrobial, Complexes, DPPH, Scavenging",
author = "Kadhum, {Abdul Amir H.} and Mohamad, {Abu Bakar} and Al-Amiery, {Ahmed A.} and Takriff, {Mohd Sobri}",
year = "2011",
month = "8",
doi = "10.3390/molecules16086969",
language = "English",
volume = "16",
pages = "6969--6984",
journal = "Molecules",
issn = "1420-3049",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "8",

}

TY - JOUR

T1 - Antimicrobial and antioxidant activities of new metal complexes derived from 3-aminocoumarin

AU - Kadhum, Abdul Amir H.

AU - Mohamad, Abu Bakar

AU - Al-Amiery, Ahmed A.

AU - Takriff, Mohd Sobri

PY - 2011/8

Y1 - 2011/8

N2 - 3-Aminocoumarin (L) has been synthesized and used as a ligand for the formation of Cr(III), Ni(II), and Cu(II) complexes. The chemical structures were characterized using different spectroscopic methods. The elemental analyses revealed that the complexes where M=Ni(II) and Cu(II) have the general formulae [ML 2Cl 2], while the Cr(III) complex has the formula [CrL 2Cl 2]Cl. The molar conductance data reveal that all the metal chelates, except the Cr(III) one, are non-electrolytes. From the magnetic and UV-Visible spectra, it is found that these complexes have octahedral structures. The stability for the prepared complexes was studied theoretically using Density Function Theory. The total energy for the complexes was calculated and it was shown that the copper complex is the most stable one. Complexes were tested against selected types of microbial organisms and showed significant activities. The free radical scavenging activity of metal complexes have been determined by measuring their interaction with the stable free radical DPPH and all the compounds have shown encouraging antioxidant activities.

AB - 3-Aminocoumarin (L) has been synthesized and used as a ligand for the formation of Cr(III), Ni(II), and Cu(II) complexes. The chemical structures were characterized using different spectroscopic methods. The elemental analyses revealed that the complexes where M=Ni(II) and Cu(II) have the general formulae [ML 2Cl 2], while the Cr(III) complex has the formula [CrL 2Cl 2]Cl. The molar conductance data reveal that all the metal chelates, except the Cr(III) one, are non-electrolytes. From the magnetic and UV-Visible spectra, it is found that these complexes have octahedral structures. The stability for the prepared complexes was studied theoretically using Density Function Theory. The total energy for the complexes was calculated and it was shown that the copper complex is the most stable one. Complexes were tested against selected types of microbial organisms and showed significant activities. The free radical scavenging activity of metal complexes have been determined by measuring their interaction with the stable free radical DPPH and all the compounds have shown encouraging antioxidant activities.

KW - 3-aminocoumarin

KW - Antimicrobial

KW - Complexes

KW - DPPH

KW - Scavenging

UR - http://www.scopus.com/inward/record.url?scp=80052256502&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=80052256502&partnerID=8YFLogxK

U2 - 10.3390/molecules16086969

DO - 10.3390/molecules16086969

M3 - Article

VL - 16

SP - 6969

EP - 6984

JO - Molecules

JF - Molecules

SN - 1420-3049

IS - 8

ER -