Antimicrobial activity and microbial transformation of ethyl p-methoxycinnamate extracted from Kaempferia Galanga

Muhammad Nor Omar, Nor Hazwani Mohd Hasali, Helmi Yousif Alfarra, Mohd. Ambar Yarmo, Ahmad Muzammil Zuberdi

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Ethyl p-methoxycinnamate (EPMC), a major constituent of the Kaempferia galanga rhizome, was transformed to ethyl p-hydroxycinnamate (EPHC) using Aspergillus niger. The EPHC metabolite was elucidated by NMR spectroscopic technique. Antimicrobial microbial study found that EPHC was active against all strains tested with a good minimum inhibitory concentration (MIC). It was active against both Staphylococcus aureus and Bacillus cereus at MIC 333 μg/ml while against Pseudomonas aeruginosa, Escherichia coli and Candida albicans at MIC 111 μg/ml. It was also shown that EPHC exhibited more growth inhibition potential than EPMC. Besides that, EPHC has shown the minimum bactericidal concentration (MBC) toward B. cereus, P. aeruginosa and E. coli at the concentration of 1000 μg/mL while EPMC did not show killing potential toward the tested microorganisms.

Original languageEnglish
Pages (from-to)1037-1043
Number of pages7
JournalOriental Journal of Chemistry
Volume30
Issue number3
DOIs
Publication statusPublished - 2014

Fingerprint

Alpinia
Zingiberaceae
antimicrobial activity
Microbial Sensitivity Tests
rhizome
Bacillus cereus
nuclear magnetic resonance
metabolite
microorganism
Pseudomonas aeruginosa
Escherichia coli
Rhizome
Aspergillus niger
Candida
Aspergillus
Metabolites
Candida albicans
Microorganisms
Staphylococcus aureus
Nuclear magnetic resonance

Keywords

  • Antimicrobial
  • Aspergillus niger
  • Biotransformation
  • Ethyl p-hydroxycinnamate
  • Ethyl p-methoxycinnamate
  • Kaempferia galanga Linn

ASJC Scopus subject areas

  • Chemistry(all)
  • Biochemistry
  • Environmental Chemistry
  • Drug Discovery

Cite this

Antimicrobial activity and microbial transformation of ethyl p-methoxycinnamate extracted from Kaempferia Galanga. / Omar, Muhammad Nor; Hasali, Nor Hazwani Mohd; Alfarra, Helmi Yousif; Yarmo, Mohd. Ambar; Zuberdi, Ahmad Muzammil.

In: Oriental Journal of Chemistry, Vol. 30, No. 3, 2014, p. 1037-1043.

Research output: Contribution to journalArticle

Omar, Muhammad Nor ; Hasali, Nor Hazwani Mohd ; Alfarra, Helmi Yousif ; Yarmo, Mohd. Ambar ; Zuberdi, Ahmad Muzammil. / Antimicrobial activity and microbial transformation of ethyl p-methoxycinnamate extracted from Kaempferia Galanga. In: Oriental Journal of Chemistry. 2014 ; Vol. 30, No. 3. pp. 1037-1043.
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AU - Zuberdi, Ahmad Muzammil

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