Antifungal garcinia acid esters from the fruits of Garcinia atroviridis

Mukram M. Mackeen, Abdul Manaf Ali, Nordin Hj Lajis, Kazuyoshi Kawazu, Hiroe Kikuzaki, Nobuji Nakatani

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Two new garcinia acid derivatives, 2-(butoxycarbonylmethyl)-3-butoxycarbonyl-2-hydroxy3-propanolide and 1′,1″-dibutyl methyl hydroxycitrate, were isolated from the fruits of Garcinia atroviridis guided by TLC bioautography against the fungus Cladosporium herbarum. The structures of these compounds were established by spectral analysis. The former compound represents a unique β-lactone structure and the latter compound is most likely an artefact of garcinia acid (= hydroxycitric acid). Both compounds showed selective antifungal activity comparable to that of cycloheximide (MID: 0.5 μg/spot) only against C. herbarum at the MIDs of 0.4 and 0.8 μg/spot but were inactive against bacteria (Bacillus subtilis, methicillin-resistant Staphylococcus aureus, Pseudomonas aeruginosa and Escherichia coli), other fungi (Alternaria sp., Fusarium moniliforme and Aspergillus ochraceous) including the yeast Candida albicans.

Original languageEnglish
Pages (from-to)291-295
Number of pages5
JournalZeitschrift fur Naturforschung - Section C Journal of Biosciences
Volume57
Issue number3-4
Publication statusPublished - 2002
Externally publishedYes

Fingerprint

Garcinia
Fruits
Cladosporium herbarum
Fruit
Esters
esters
fruits
acids
Fungi
fungi
Propiolactone
Alternaria
cycloheximide
lactones
Cladosporium
Candida albicans
Pseudomonas aeruginosa
Aspergillus
Bacillus subtilis
spectral analysis

Keywords

  • β-Lactone
  • Fruits
  • Garcinia atroviridis

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry

Cite this

Antifungal garcinia acid esters from the fruits of Garcinia atroviridis. / Mackeen, Mukram M.; Ali, Abdul Manaf; Lajis, Nordin Hj; Kawazu, Kazuyoshi; Kikuzaki, Hiroe; Nakatani, Nobuji.

In: Zeitschrift fur Naturforschung - Section C Journal of Biosciences, Vol. 57, No. 3-4, 2002, p. 291-295.

Research output: Contribution to journalArticle

Mackeen, MM, Ali, AM, Lajis, NH, Kawazu, K, Kikuzaki, H & Nakatani, N 2002, 'Antifungal garcinia acid esters from the fruits of Garcinia atroviridis', Zeitschrift fur Naturforschung - Section C Journal of Biosciences, vol. 57, no. 3-4, pp. 291-295.
Mackeen, Mukram M. ; Ali, Abdul Manaf ; Lajis, Nordin Hj ; Kawazu, Kazuyoshi ; Kikuzaki, Hiroe ; Nakatani, Nobuji. / Antifungal garcinia acid esters from the fruits of Garcinia atroviridis. In: Zeitschrift fur Naturforschung - Section C Journal of Biosciences. 2002 ; Vol. 57, No. 3-4. pp. 291-295.
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