Antifungal activity of the essential oils of nine Zingiberaceae species

Ibrahim Jantan, Mohd Salleh Mohd Yassin, Chen Bee Chin, Lau Lee Chen, Ng Lee Sim

Research output: Contribution to journalArticle

86 Citations (Scopus)

Abstract

The rhizome oils of nine Zingiberaceae species [Zingiber officinale Rosc., Z. cassumunar Roxb., Z. zerumbet Smith, Curcuma aeruginosa Roxb., C. mangga Valeton and van Zyp, C. xanthorrhiza Roxb., Kaempferia galanga Linn., Alpinia galanga Swartz and Boesenbergia pandurata (Roxb.) Schlecht] were investigated for their antifungal activities against five dermatophytes (Trichophyton mentagrophytes, T. rubrum, Microsporum canis, M. nahum and Epidermophyton floccosum), three filamentous fungi (Aspergillus niger, A. fumigatus and Mucor sp.) and five strains of yeast (Saccharomyces cerevisiae, Cryptococcus neoformans, Candida albicans, Ca. tropicalis and Torulopsis glabrata). The antifungal testing was carried out by using the broth microdilution and the disc gel diffusion methods. Amongst the essential oils studied, only the oil of B. pandurata was effective against all the fungi, exhibiting the lowest MIC values of 0.63 μg μl-1 to Mucor. sp., 1.25 μg μl -1 to both A. niger and A. fumigatus, and 2.5 μg μl -1 to both T. rubrum and E. floccosum, and the highest inhibition zone diameter of 20.6 mm against S. cerevisiae. The essential oil of K. galanga showed selective toxicity against A. fumigatus with a MIC value of 0.63 μg μl-1, while the essential oils of Z. officinale and Z. cassumunar exhibited high activity against the yeasts (11.7-15.7 mm). The chemical composition of the active essential oils was investigated by GC and GC-MS.

Original languageEnglish
Pages (from-to)392-397
Number of pages6
JournalPharmaceutical Biology
Volume41
Issue number5
DOIs
Publication statusPublished - Aug 2003

Fingerprint

Zingiberaceae
Alpinia
Volatile Oils
Yeast
essential oils
Epidermophyton floccosum
Ginger
Mucor
Zingiber officinale
Aspergillus niger
Fungi
Curcuma aeruginosa
Saccharomyces cerevisiae
Curcuma mangga
Zingiber montanum
Curcuma zanthorrhiza
Oils
Zingiber zerumbet
Alpinia galanga
Yeasts

Keywords

  • Antifungal activity
  • Broth microdilution
  • Dermatophytes
  • Disc gel diffusion
  • Essential oils
  • Filamentous fungi
  • Yeasts
  • Zingiberaceae species

ASJC Scopus subject areas

  • Plant Science
  • Medical Laboratory Technology
  • Clinical Biochemistry
  • Pharmacology

Cite this

Jantan, I., Mohd Yassin, M. S., Chin, C. B., Chen, L. L., & Sim, N. L. (2003). Antifungal activity of the essential oils of nine Zingiberaceae species. Pharmaceutical Biology, 41(5), 392-397. https://doi.org/10.1076/phbi.41.5.392.15941

Antifungal activity of the essential oils of nine Zingiberaceae species. / Jantan, Ibrahim; Mohd Yassin, Mohd Salleh; Chin, Chen Bee; Chen, Lau Lee; Sim, Ng Lee.

In: Pharmaceutical Biology, Vol. 41, No. 5, 08.2003, p. 392-397.

Research output: Contribution to journalArticle

Jantan, I, Mohd Yassin, MS, Chin, CB, Chen, LL & Sim, NL 2003, 'Antifungal activity of the essential oils of nine Zingiberaceae species', Pharmaceutical Biology, vol. 41, no. 5, pp. 392-397. https://doi.org/10.1076/phbi.41.5.392.15941
Jantan, Ibrahim ; Mohd Yassin, Mohd Salleh ; Chin, Chen Bee ; Chen, Lau Lee ; Sim, Ng Lee. / Antifungal activity of the essential oils of nine Zingiberaceae species. In: Pharmaceutical Biology. 2003 ; Vol. 41, No. 5. pp. 392-397.
@article{5faf65f089fb449780cdfe9917858778,
title = "Antifungal activity of the essential oils of nine Zingiberaceae species",
abstract = "The rhizome oils of nine Zingiberaceae species [Zingiber officinale Rosc., Z. cassumunar Roxb., Z. zerumbet Smith, Curcuma aeruginosa Roxb., C. mangga Valeton and van Zyp, C. xanthorrhiza Roxb., Kaempferia galanga Linn., Alpinia galanga Swartz and Boesenbergia pandurata (Roxb.) Schlecht] were investigated for their antifungal activities against five dermatophytes (Trichophyton mentagrophytes, T. rubrum, Microsporum canis, M. nahum and Epidermophyton floccosum), three filamentous fungi (Aspergillus niger, A. fumigatus and Mucor sp.) and five strains of yeast (Saccharomyces cerevisiae, Cryptococcus neoformans, Candida albicans, Ca. tropicalis and Torulopsis glabrata). The antifungal testing was carried out by using the broth microdilution and the disc gel diffusion methods. Amongst the essential oils studied, only the oil of B. pandurata was effective against all the fungi, exhibiting the lowest MIC values of 0.63 μg μl-1 to Mucor. sp., 1.25 μg μl -1 to both A. niger and A. fumigatus, and 2.5 μg μl -1 to both T. rubrum and E. floccosum, and the highest inhibition zone diameter of 20.6 mm against S. cerevisiae. The essential oil of K. galanga showed selective toxicity against A. fumigatus with a MIC value of 0.63 μg μl-1, while the essential oils of Z. officinale and Z. cassumunar exhibited high activity against the yeasts (11.7-15.7 mm). The chemical composition of the active essential oils was investigated by GC and GC-MS.",
keywords = "Antifungal activity, Broth microdilution, Dermatophytes, Disc gel diffusion, Essential oils, Filamentous fungi, Yeasts, Zingiberaceae species",
author = "Ibrahim Jantan and {Mohd Yassin}, {Mohd Salleh} and Chin, {Chen Bee} and Chen, {Lau Lee} and Sim, {Ng Lee}",
year = "2003",
month = "8",
doi = "10.1076/phbi.41.5.392.15941",
language = "English",
volume = "41",
pages = "392--397",
journal = "Pharmaceutical Biology",
issn = "1388-0209",
publisher = "Informa Healthcare",
number = "5",

}

TY - JOUR

T1 - Antifungal activity of the essential oils of nine Zingiberaceae species

AU - Jantan, Ibrahim

AU - Mohd Yassin, Mohd Salleh

AU - Chin, Chen Bee

AU - Chen, Lau Lee

AU - Sim, Ng Lee

PY - 2003/8

Y1 - 2003/8

N2 - The rhizome oils of nine Zingiberaceae species [Zingiber officinale Rosc., Z. cassumunar Roxb., Z. zerumbet Smith, Curcuma aeruginosa Roxb., C. mangga Valeton and van Zyp, C. xanthorrhiza Roxb., Kaempferia galanga Linn., Alpinia galanga Swartz and Boesenbergia pandurata (Roxb.) Schlecht] were investigated for their antifungal activities against five dermatophytes (Trichophyton mentagrophytes, T. rubrum, Microsporum canis, M. nahum and Epidermophyton floccosum), three filamentous fungi (Aspergillus niger, A. fumigatus and Mucor sp.) and five strains of yeast (Saccharomyces cerevisiae, Cryptococcus neoformans, Candida albicans, Ca. tropicalis and Torulopsis glabrata). The antifungal testing was carried out by using the broth microdilution and the disc gel diffusion methods. Amongst the essential oils studied, only the oil of B. pandurata was effective against all the fungi, exhibiting the lowest MIC values of 0.63 μg μl-1 to Mucor. sp., 1.25 μg μl -1 to both A. niger and A. fumigatus, and 2.5 μg μl -1 to both T. rubrum and E. floccosum, and the highest inhibition zone diameter of 20.6 mm against S. cerevisiae. The essential oil of K. galanga showed selective toxicity against A. fumigatus with a MIC value of 0.63 μg μl-1, while the essential oils of Z. officinale and Z. cassumunar exhibited high activity against the yeasts (11.7-15.7 mm). The chemical composition of the active essential oils was investigated by GC and GC-MS.

AB - The rhizome oils of nine Zingiberaceae species [Zingiber officinale Rosc., Z. cassumunar Roxb., Z. zerumbet Smith, Curcuma aeruginosa Roxb., C. mangga Valeton and van Zyp, C. xanthorrhiza Roxb., Kaempferia galanga Linn., Alpinia galanga Swartz and Boesenbergia pandurata (Roxb.) Schlecht] were investigated for their antifungal activities against five dermatophytes (Trichophyton mentagrophytes, T. rubrum, Microsporum canis, M. nahum and Epidermophyton floccosum), three filamentous fungi (Aspergillus niger, A. fumigatus and Mucor sp.) and five strains of yeast (Saccharomyces cerevisiae, Cryptococcus neoformans, Candida albicans, Ca. tropicalis and Torulopsis glabrata). The antifungal testing was carried out by using the broth microdilution and the disc gel diffusion methods. Amongst the essential oils studied, only the oil of B. pandurata was effective against all the fungi, exhibiting the lowest MIC values of 0.63 μg μl-1 to Mucor. sp., 1.25 μg μl -1 to both A. niger and A. fumigatus, and 2.5 μg μl -1 to both T. rubrum and E. floccosum, and the highest inhibition zone diameter of 20.6 mm against S. cerevisiae. The essential oil of K. galanga showed selective toxicity against A. fumigatus with a MIC value of 0.63 μg μl-1, while the essential oils of Z. officinale and Z. cassumunar exhibited high activity against the yeasts (11.7-15.7 mm). The chemical composition of the active essential oils was investigated by GC and GC-MS.

KW - Antifungal activity

KW - Broth microdilution

KW - Dermatophytes

KW - Disc gel diffusion

KW - Essential oils

KW - Filamentous fungi

KW - Yeasts

KW - Zingiberaceae species

UR - http://www.scopus.com/inward/record.url?scp=0141539490&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0141539490&partnerID=8YFLogxK

U2 - 10.1076/phbi.41.5.392.15941

DO - 10.1076/phbi.41.5.392.15941

M3 - Article

AN - SCOPUS:0141539490

VL - 41

SP - 392

EP - 397

JO - Pharmaceutical Biology

JF - Pharmaceutical Biology

SN - 1388-0209

IS - 5

ER -