Antifertility effect of goniothalamin

A styrylpyrone isolated from Goniothalamus tapis miqo

L. P. Azimahtol Hawariah, M. Munawer, L. B. Din

    Research output: Contribution to journalArticle

    18 Citations (Scopus)

    Abstract

    This study was designed to investigate the effect of goniothalamin, a styrylpyrone derivative extracted from Goniothalamus tapis (Annonaceae) on early pregnant mice. Treatment with goniothalamin intraperitoneally at the dose of 138.9 mg kg-1 body weight from day 1 to day 7 of gestation prevented the normal maintenance of pregnancy. Serum level of progesterone in goniothalamin-treated mice was found to be significantly (p < 0.01) lower than the control group while the luteinising hormone levels were significantly (p < 0.001) higher on days 5 and 6. The uterus wet weight was also significantly (p < 0.001) lower than the control, an indication that the animals were not pregnant. The failure to maintain pregnancy could be attributed to a direct or indirect effect on the corpus luteum which may result in the inhibition of the synthesis and/or the secretion of progesterone by the corpus luteum.

    Original languageEnglish
    Pages (from-to)273-277
    Number of pages5
    JournalAsia Pacific Journal of Pharmacology
    Volume9
    Issue number4
    Publication statusPublished - 1994

    Fingerprint

    Goniothalamus
    Corpus Luteum
    Progesterone
    Annonaceae
    Pregnancy Maintenance
    Pregnancy
    Luteinizing Hormone
    Uterus
    Body Weight
    Weights and Measures
    Control Groups
    Serum
    goniothalamin

    Keywords

    • antifertility
    • goniothalamin
    • luteinising hormone
    • mouse
    • progesterone

    ASJC Scopus subject areas

    • Pharmacology

    Cite this

    Antifertility effect of goniothalamin : A styrylpyrone isolated from Goniothalamus tapis miqo. / Azimahtol Hawariah, L. P.; Munawer, M.; Din, L. B.

    In: Asia Pacific Journal of Pharmacology, Vol. 9, No. 4, 1994, p. 273-277.

    Research output: Contribution to journalArticle

    Azimahtol Hawariah, L. P. ; Munawer, M. ; Din, L. B. / Antifertility effect of goniothalamin : A styrylpyrone isolated from Goniothalamus tapis miqo. In: Asia Pacific Journal of Pharmacology. 1994 ; Vol. 9, No. 4. pp. 273-277.
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