Antibacterial activity and major constituents of polyalthia cinnamomea basic fraction

Puteri I.A.M. Mahmud, Wan Yaacob Wan Ahmad, Nazlina Ibrahim, Muntaz Abu Bakar

Research output: Contribution to journalArticle

Abstract

Polyalthia cinnamomea Hook.f. & Thomson (Annonaceae) or locally known as ‘Larak Batu Bukit’, ‘Pisang-pisang’, ‘Sugao’ and ‘Sigumpet Hutan’ is a small woody plant found throughout Malaysia and Singapore. In this study, the basic chemical components from the leaves of the plant were fractionated and the antibacterial activity as well as the major constituents of the basic fraction was determined. To the best of our knowledge, this is the first study being carried out on the bioactivity and phytochemistry of P. cinnamomea. The basic fraction remarkably inhibited the growth of ten bacteria tested except one. The biggest inhibitory diameter and the lowest minimum inhibitory concentration were 19.0±4.6 mm and 0.125 mg/mL against respective Bacillus subtilis and Bacillus thuringiensis. Gas chromatography-mass spectrometry (GCMS) analysis of the basic fraction identified four major cyclosiloxanes of octamethylcyclotetrasiloxane (18.1%), decamethylcyclopentasiloxane (16.4%), dodecamethylcyclohexasiloxane (14.1%) and tetradecamethylcycloheptasiloxane (6.0%). The knowledge of the antibacterial potential of P. cinnamomea basic fraction and the major constituents present in the fraction can be utilized in the fields of natural products, pharmaceutical, cosmetic and personel care industries.

Original languageEnglish
Pages (from-to)2063-2071
Number of pages9
JournalSains Malaysiana
Volume47
Issue number9
DOIs
Publication statusPublished - 1 Jan 2018

Fingerprint

Polyalthia
Annonaceae
plant biochemistry
Singapore
cosmetics
minimum inhibitory concentration
woody plants
Bacillus thuringiensis
Bacillus subtilis
Malaysia
industry
drugs
bacteria
leaves
gas chromatography-mass spectrometry

Keywords

  • Antibacterial activity
  • Basic fraction
  • Cyclosiloxane
  • Polyalthia cinnamomea

ASJC Scopus subject areas

  • General

Cite this

Antibacterial activity and major constituents of polyalthia cinnamomea basic fraction. / Mahmud, Puteri I.A.M.; Wan Ahmad, Wan Yaacob; Ibrahim, Nazlina; Abu Bakar, Muntaz.

In: Sains Malaysiana, Vol. 47, No. 9, 01.01.2018, p. 2063-2071.

Research output: Contribution to journalArticle

Mahmud, Puteri I.A.M. ; Wan Ahmad, Wan Yaacob ; Ibrahim, Nazlina ; Abu Bakar, Muntaz. / Antibacterial activity and major constituents of polyalthia cinnamomea basic fraction. In: Sains Malaysiana. 2018 ; Vol. 47, No. 9. pp. 2063-2071.
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