Antiallodynic and antihyperalgesic effects of zerumbone on a mouse model of chronic constriction injury-induced neuropathic pain

Nurul Atiqah Zulazmi, Banulata Gopalsamy, Ahmad Akira Omar Farouk, Mohd Roslan Sulaiman, B. Hemabarathy Bharatham, Enoch Kumar Perimal

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Abstract Neuropathic pain is a chronic condition that is difficult to be treated. Current therapies available are either ineffective or non-specific thus requiring newer treatment approaches. In this study, we investigated the antiallodynic and antihyperalgesic effects of zerumbone, a bioactive sesquiterpene from Zingiber zerumbet in chronic constriction injury (CCI)-induced neuropathic pain animal model. Our findings showed that single and repeated dose of intra-peritoneal administration of zerumbone (5, 10, 50, 100 mg/kg) significantly attenuated the CCI-induced neuropathic pain when evaluated using the electronic von Frey anesthesiometer, cold plate, Randall-Selitto analgesiometer and the Hargreaves plantar test. Zerumbone significantly alleviated tactile and cold allodynia as well as mechanical and thermal hyperalgesia. Our findings are in comparison to the positive control drugs thatused gabapentin (20 mg/kg i.p.) and morphine (1 mg/kg i.p.). Together, these results showed that the systemic administration of zerumbone produced marked antiallodynic and antihyperalgesic effects in the CCI-induced neuropathic pain in mice and may serve as a potential lead compound for further analysis.

Original languageEnglish
Article number3228
Pages (from-to)215-221
Number of pages7
JournalFitoterapia
Volume105
DOIs
Publication statusPublished - 25 Jul 2015

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Neuralgia
Constriction
Hyperalgesia
Wounds and Injuries
Sesquiterpenes
Drug and Narcotic Control
Morphine
Animal Models
zerumbone
Therapeutics

Keywords

  • CCI
  • Neuropathic pain
  • Zerumbone
  • Zingiber zerumbet

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

Cite this

Antiallodynic and antihyperalgesic effects of zerumbone on a mouse model of chronic constriction injury-induced neuropathic pain. / Zulazmi, Nurul Atiqah; Gopalsamy, Banulata; Omar Farouk, Ahmad Akira; Sulaiman, Mohd Roslan; Bharatham, B. Hemabarathy; Perimal, Enoch Kumar.

In: Fitoterapia, Vol. 105, 3228, 25.07.2015, p. 215-221.

Research output: Contribution to journalArticle

Zulazmi, Nurul Atiqah ; Gopalsamy, Banulata ; Omar Farouk, Ahmad Akira ; Sulaiman, Mohd Roslan ; Bharatham, B. Hemabarathy ; Perimal, Enoch Kumar. / Antiallodynic and antihyperalgesic effects of zerumbone on a mouse model of chronic constriction injury-induced neuropathic pain. In: Fitoterapia. 2015 ; Vol. 105. pp. 215-221.
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