Anti-inflammatory trends of 1, 3-Diphenyl-2-propen-1-one derivatives

Bukhari Syed Nasir Abbas, Ibrahim Jantan, Malina Jasamai

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

Chalcones (1, 3-Diphenyl-2-propen-1-one) are constituted by a three carbon α, β-unsaturated carbonyl system. The biosynthesis of flavonoids and isoflavonoids is initiated by chalcones. Notable pharmacological activities of chalcones and its derivatives include anti-inflammatory, antifungal, antibacterial, antimalarial, antituberculosis, antitumor, antimicrobial and antiviral effects respectively. Owing to simplicity of the chemical structures and a huge variety of pharmacological actions exhibited, the entities derived from chalcones are subjected to extensive consideration. This review article is an effort to sum up the anti-inflammatory activities of chalcone derived chemical entities. Effect of chalcones on lipid peroxidation, heme oxygenase 1(HO-1), cyclooxygenase (COX), interleukin 5 (IL-5), nitric oxide (NO) and expression of cell adhesion molecules (CAM) is summarized stepwise.

Original languageEnglish
Pages (from-to)87-94
Number of pages8
JournalMini-Reviews in Medicinal Chemistry
Volume13
Issue number1
Publication statusPublished - 2013

Fingerprint

Chalcones
Chalcone
Anti-Inflammatory Agents
Pharmacology
Heme Oxygenase-1
Interleukin-5
Antimalarials
Cell Adhesion Molecules
Prostaglandin-Endoperoxide Synthases
Flavonoids
Lipid Peroxidation
Antiviral Agents
Nitric Oxide
Carbon

Keywords

  • Anti-inflammatory
  • Chalcones
  • Cyclooxygenase (COX)
  • Heme oxygenase1(HO-1)
  • Interleukin 5 (IL-5)
  • Lipid peroxidation
  • Nitric oxide (NO)

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

Cite this

Anti-inflammatory trends of 1, 3-Diphenyl-2-propen-1-one derivatives. / Syed Nasir Abbas, Bukhari; Jantan, Ibrahim; Jasamai, Malina.

In: Mini-Reviews in Medicinal Chemistry, Vol. 13, No. 1, 2013, p. 87-94.

Research output: Contribution to journalArticle

Syed Nasir Abbas, Bukhari ; Jantan, Ibrahim ; Jasamai, Malina. / Anti-inflammatory trends of 1, 3-Diphenyl-2-propen-1-one derivatives. In: Mini-Reviews in Medicinal Chemistry. 2013 ; Vol. 13, No. 1. pp. 87-94.
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