Anti-inflammatory effect of Curcuma longa (turmeric) on collagen-induced arthritis

An anatomico-radiological study

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Introduction and Objective: Curcuma longa (CL) or turmeric is an Ayurvedic herb that has been traditionally used to treat inflammatory conditions like rheumatoid arthritis (RA). Collagen-induced arthritis (CIA) is a well established experimental auto-immune mediated polyarthritis in susceptible strains of rodents. The main aim of the study was to observe the inflammatory, macroscopic and radiological changes in the arthritic ankle joints of experimentally collagen-induced arthritis animals treated with or without CL extract. Materials and Methods: Thirty six male Sprague-Dawley (6-8 weeks-old, 150 ± 50) rats were equally divided into six groups. The first group served as a control while the rest five groups were immunized subdermally with 150 μg collagen type-II on day-0. All rats with established CIA with arthritis score (AS) exceeding 1 were treated orally with betamethasone (0.5 mg/ml/kg body weight) and varying doses of CL extract (30, 60 and 110 mg/ml/kg body weight) using olive oil as vehicle, daily for four weeks. Arthritic scoring (AS) of the paws, measurement of erythrocyte sedimentation rate (ESR) and paw thickness and radiological scoring were performed. Results: Treatment with 110 mg/ml/kg CL showed significant mean difference in the ESR (p<0.01), AS (p<0.05) and radiological scores (p<0.01) on day-28 compared to the vehicle treated group. The mean difference for the ESR, AS and radiological scores of this highest CL dose group were found to be insignificant compared to the betamethasone treated group. Conclusion: The administration of CL extract arrested the degenerative changes in the bone and joints of collagen-induced arthritic rats.

Original languageEnglish
Pages (from-to)201-207
Number of pages7
JournalClinica Terapeutica
Volume162
Issue number3
Publication statusPublished - 2011

Fingerprint

Curcuma
Experimental Arthritis
Anti-Inflammatory Agents
Arthritis
Blood Sedimentation
Betamethasone
Body Weight
Ankle Joint
Collagen Type II
Rodentia
Rheumatoid Arthritis
Joints
Bone and Bones

Keywords

  • Anatomy
  • Arthritis
  • Curcuma longa
  • Experimental
  • Joints
  • Radiology
  • Rats
  • Turmeric

ASJC Scopus subject areas

  • Medicine(all)

Cite this

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title = "Anti-inflammatory effect of Curcuma longa (turmeric) on collagen-induced arthritis: An anatomico-radiological study",
abstract = "Introduction and Objective: Curcuma longa (CL) or turmeric is an Ayurvedic herb that has been traditionally used to treat inflammatory conditions like rheumatoid arthritis (RA). Collagen-induced arthritis (CIA) is a well established experimental auto-immune mediated polyarthritis in susceptible strains of rodents. The main aim of the study was to observe the inflammatory, macroscopic and radiological changes in the arthritic ankle joints of experimentally collagen-induced arthritis animals treated with or without CL extract. Materials and Methods: Thirty six male Sprague-Dawley (6-8 weeks-old, 150 ± 50) rats were equally divided into six groups. The first group served as a control while the rest five groups were immunized subdermally with 150 μg collagen type-II on day-0. All rats with established CIA with arthritis score (AS) exceeding 1 were treated orally with betamethasone (0.5 mg/ml/kg body weight) and varying doses of CL extract (30, 60 and 110 mg/ml/kg body weight) using olive oil as vehicle, daily for four weeks. Arthritic scoring (AS) of the paws, measurement of erythrocyte sedimentation rate (ESR) and paw thickness and radiological scoring were performed. Results: Treatment with 110 mg/ml/kg CL showed significant mean difference in the ESR (p<0.01), AS (p<0.05) and radiological scores (p<0.01) on day-28 compared to the vehicle treated group. The mean difference for the ESR, AS and radiological scores of this highest CL dose group were found to be insignificant compared to the betamethasone treated group. Conclusion: The administration of CL extract arrested the degenerative changes in the bone and joints of collagen-induced arthritic rats.",
keywords = "Anatomy, Arthritis, Curcuma longa, Experimental, Joints, Radiology, Rats, Turmeric",
author = "Kamarudin, {Taty Anna} and {Mohd Ramli}, {Elvy Suhana} and Srijit Das and Faizah Othman and {Abdul Hamid}, Hamzaini",
year = "2011",
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T1 - Anti-inflammatory effect of Curcuma longa (turmeric) on collagen-induced arthritis

T2 - An anatomico-radiological study

AU - Kamarudin, Taty Anna

AU - Mohd Ramli, Elvy Suhana

AU - Das, Srijit

AU - Othman, Faizah

AU - Abdul Hamid, Hamzaini

PY - 2011

Y1 - 2011

N2 - Introduction and Objective: Curcuma longa (CL) or turmeric is an Ayurvedic herb that has been traditionally used to treat inflammatory conditions like rheumatoid arthritis (RA). Collagen-induced arthritis (CIA) is a well established experimental auto-immune mediated polyarthritis in susceptible strains of rodents. The main aim of the study was to observe the inflammatory, macroscopic and radiological changes in the arthritic ankle joints of experimentally collagen-induced arthritis animals treated with or without CL extract. Materials and Methods: Thirty six male Sprague-Dawley (6-8 weeks-old, 150 ± 50) rats were equally divided into six groups. The first group served as a control while the rest five groups were immunized subdermally with 150 μg collagen type-II on day-0. All rats with established CIA with arthritis score (AS) exceeding 1 were treated orally with betamethasone (0.5 mg/ml/kg body weight) and varying doses of CL extract (30, 60 and 110 mg/ml/kg body weight) using olive oil as vehicle, daily for four weeks. Arthritic scoring (AS) of the paws, measurement of erythrocyte sedimentation rate (ESR) and paw thickness and radiological scoring were performed. Results: Treatment with 110 mg/ml/kg CL showed significant mean difference in the ESR (p<0.01), AS (p<0.05) and radiological scores (p<0.01) on day-28 compared to the vehicle treated group. The mean difference for the ESR, AS and radiological scores of this highest CL dose group were found to be insignificant compared to the betamethasone treated group. Conclusion: The administration of CL extract arrested the degenerative changes in the bone and joints of collagen-induced arthritic rats.

AB - Introduction and Objective: Curcuma longa (CL) or turmeric is an Ayurvedic herb that has been traditionally used to treat inflammatory conditions like rheumatoid arthritis (RA). Collagen-induced arthritis (CIA) is a well established experimental auto-immune mediated polyarthritis in susceptible strains of rodents. The main aim of the study was to observe the inflammatory, macroscopic and radiological changes in the arthritic ankle joints of experimentally collagen-induced arthritis animals treated with or without CL extract. Materials and Methods: Thirty six male Sprague-Dawley (6-8 weeks-old, 150 ± 50) rats were equally divided into six groups. The first group served as a control while the rest five groups were immunized subdermally with 150 μg collagen type-II on day-0. All rats with established CIA with arthritis score (AS) exceeding 1 were treated orally with betamethasone (0.5 mg/ml/kg body weight) and varying doses of CL extract (30, 60 and 110 mg/ml/kg body weight) using olive oil as vehicle, daily for four weeks. Arthritic scoring (AS) of the paws, measurement of erythrocyte sedimentation rate (ESR) and paw thickness and radiological scoring were performed. Results: Treatment with 110 mg/ml/kg CL showed significant mean difference in the ESR (p<0.01), AS (p<0.05) and radiological scores (p<0.01) on day-28 compared to the vehicle treated group. The mean difference for the ESR, AS and radiological scores of this highest CL dose group were found to be insignificant compared to the betamethasone treated group. Conclusion: The administration of CL extract arrested the degenerative changes in the bone and joints of collagen-induced arthritic rats.

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KW - Joints

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