Anti-cyclic citrullinated peptide antibody is a good indicator for the diagnosis of rheumatoid arthritis

Asrul Abdul Wahab, Marlyn Mohammad, Md. Mostafizur Rahman, Mohd Shahrir Mohamed Said

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Objectives: Anti-cyclic citrullinated peptide (CCP) antibody has recently been used in the classification of rheumatoid arthritis (RA). This antibody is more specific than rheumatoid factor (RF) for the diagnosis of RA. The study objectives were to determine the sensitivity, specificity, positive and negative predictive values of anti-CCP in RA diagnosis. Methodology: Eighty RA patients and 80 non-RA individuals were included in the study. Blood was collected from both arms of study subjects and tested for anti-CCP and RF antibodies. Relevant clinical information and laboratory profiles of the RA patients were evaluated using patients' medical records and Integrated Laboratory Management System (ILMS), respectively. Results: The sensitivity and specificity of anti-CCP were 35% and 100% respectively. The positive and negative predictive values were 100% and 61%, respectively. Positive anti-CCP was found significantly associated with multiple joint pain (p < 0.001) and hand's joints pain (p=0.01), symmetrical joints involvement (p=0.015) and high CRP value (p < 0.001). Anti-CCP was also found to have positive association with RF (p < 0.001). Conclusion: Anti-CCP is highly specific for the diagnosis of RA. High positive predictive value should be taken into consideration for effective treatment.

Original languageEnglish
JournalPakistan Journal of Medical Sciences
Volume29
Issue number3
DOIs
Publication statusPublished - 11 Sep 2012

Fingerprint

Rheumatoid Arthritis
Antibodies
Rheumatoid Factor
Arthralgia
Hand Joints
Sensitivity and Specificity
cyclic citrullinated peptide
Arthritis
Medical Records
Joints

Keywords

  • Anti-CCP
  • Negative predictive value
  • Positive predictive value
  • Rheumatoid arthritis
  • Rheumatoid factor
  • Sensitivity
  • Specificity

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Anti-cyclic citrullinated peptide antibody is a good indicator for the diagnosis of rheumatoid arthritis. / Abdul Wahab, Asrul; Mohammad, Marlyn; Rahman, Md. Mostafizur; Mohamed Said, Mohd Shahrir.

In: Pakistan Journal of Medical Sciences, Vol. 29, No. 3, 11.09.2012.

Research output: Contribution to journalArticle

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