Animal models of metabolic syndrome: a review

Sok Kuan Wong, Chin Kok Yong, Farihah Suhaimi, Fairus Ahmad, Ima Nirwana Soelaiman

Research output: Contribution to journalReview article

68 Citations (Scopus)

Abstract

Metabolic syndrome (MetS) consists of several medical conditions that collectively predict the risk for cardiovascular disease better than the sum of individual conditions. The risk of developing MetS in human depends on synergy of both genetic and environmental factors. Being a multifactorial condition with alarming rate of prevalence nowadays, establishment of appropriate experimental animal models mimicking the disease state in humans is crucial in order to solve the difficulties in evaluating the pathophysiology of MetS in human. This review aims to summarize the underlying mechanisms involved in the pathophysiology of dietary, genetic, and pharmacological models of MetS. Furthermore, we will discuss the usefulness, suitability, pros and cons of these animal models. Even though numerous animal models of MetS have been established, further investigations on the invention of new animal model and clarification of plausible mechanisms are still necessary to confer a better understanding to researchers on the selection of animal models for their studies.

Original languageEnglish
Pages (from-to)1-12
Number of pages12
JournalNutrition and Metabolism
Volume13
Issue number1
DOIs
Publication statusPublished - 4 Oct 2016

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Animal Models
Genetic Models
Cardiovascular Diseases
Research Personnel
Pharmacology

Keywords

  • Antipsychotic drugs
  • Carbohydrate
  • Fat
  • Fructose
  • Glucocorticoid
  • Leptin
  • Sucrose

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

Cite this

Animal models of metabolic syndrome : a review. / Wong, Sok Kuan; Kok Yong, Chin; Suhaimi, Farihah; Ahmad, Fairus; Soelaiman, Ima Nirwana.

In: Nutrition and Metabolism, Vol. 13, No. 1, 04.10.2016, p. 1-12.

Research output: Contribution to journalReview article

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