Animal Models in Cardiovascular Research

Hypertension and Atherosclerosis

Xin Fang Leong, Chun Yi Ng, Kamsiah Jaarin

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

Hypertension and atherosclerosis are among the most common causes of mortality in both developed and developing countries. Experimental animal models of hypertension and atherosclerosis have become a valuable tool for providing information on etiology, pathophysiology, and complications of the disease and on the efficacy and mechanism of action of various drugs and compounds used in treatment. An animal model has been developed to study hypertension and atherosclerosis for several reasons. Compared to human models, an animal model is easily manageable, as compounding effects of dietary and environmental factors can be controlled. Blood vessels and cardiac tissue samples can be taken for detailed experimental and biomolecular examination. Choice of animal model is often determined by the research aim, as well as financial and technical factors. A thorough understanding of the animal models used and complete analysis must be validated so that the data can be extrapolated to humans. In conclusion, animal models for hypertension and atherosclerosis are invaluable in improving our understanding of cardiovascular disease and developing new pharmacological therapies.

Original languageEnglish
Article number528757
JournalBioMed Research International
Volume2015
DOIs
Publication statusPublished - 2015

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Atherosclerosis
Animals
Animal Models
Hypertension
Research
Developed Countries
Blood vessels
Developing Countries
Blood Vessels
Developing countries
Cardiovascular Diseases
Pharmacology
Tissue
Mortality
Pharmaceutical Preparations
Therapeutics

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

Cite this

Animal Models in Cardiovascular Research : Hypertension and Atherosclerosis. / Leong, Xin Fang; Ng, Chun Yi; Jaarin, Kamsiah.

In: BioMed Research International, Vol. 2015, 528757, 2015.

Research output: Contribution to journalArticle

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