Angioinvasive cerebral aspergillosis presenting as acute ischaemic stroke in a patient with diabetes mellitus

Norlinah Mohamed Ibrahim, H. A. Ngow, B. B. Hamidon

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Cerebral angioinvasive aspergillosis is a rare manifestation of disseminated aspergillosis which may result in stroke in immunocompromised individuals. Reports of such disease in patients with diabetes mellitus are rare. We describe a 45-year-old man with diabetes mellitus who presented with a three-day history of rightsided limb weakness and aphasia. Cerebral computed tomography showed features of an acute infarct involving the left anterior and middle cerebral arteries. He was initially treated for an acute ischaemic stroke. Further history revealed that he was investigated for a growth in the sphenoid sinus two months earlier. Culture of the biopsied material from the sphenoid sinus grew Aspergillus fumigatus. Magnetic resonance imaging showed an extension of the growth to the brain, causing the acute ischaemic stroke. He was subsequently diagnosed with angioinvasive cerebral aspergillosis and was commenced on intravenous amphotericin B. Unfortunately, he succumbed to his illness despite treatment.

Original languageEnglish
JournalSingapore Medical Journal
Volume48
Issue number1
Publication statusPublished - Jan 2007

Fingerprint

Aspergillosis
Sphenoid Sinus
Diabetes Mellitus
Stroke
Anterior Cerebral Artery
Aspergillus fumigatus
Aphasia
Middle Cerebral Artery
Amphotericin B
Growth
Extremities
History
Tomography
Magnetic Resonance Imaging
Brain
Therapeutics

Keywords

  • Acute stroke
  • Angioinvasive cerebral aspergillosis
  • Aspergillus fumigatus
  • Brain infection
  • Diabetes mellitus

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Angioinvasive cerebral aspergillosis presenting as acute ischaemic stroke in a patient with diabetes mellitus. / Mohamed Ibrahim, Norlinah; Ngow, H. A.; Hamidon, B. B.

In: Singapore Medical Journal, Vol. 48, No. 1, 01.2007.

Research output: Contribution to journalArticle

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