Analyzing the Secretome of Gut Microbiota as the Next Strategy For Early Detection of Colorectal Cancer

Putri Intan Hafizah Megat Mohd Azlan, Siok Fong Chin, Low Teck Yew, Hui Min Neoh, A. Rahman A. Jamal

Research output: Contribution to journalArticle

Abstract

Dysbiosis of gut microbiome can contribute to inflammation, and subsequently initiation and progression of colorectal cancer (CRC). Throughout these stages, various proteins and metabolites are secreted to the external environment by microorganisms or the hosts themselves. Studying these proteins may help enhance our understanding of the host–microorganism relationship or they may even serve as useful biomarkers for CRC. However, secretomic studies of gut microbiome of CRC patients, until now, are scarcely performed. In this review article, the focus is on the roles of gut microbiome in CRC, the current findings on CRC secretome are highlighted, and the emerging challenges and strategies to drive forward this area of research are addressed.

Original languageEnglish
Article number1800176
JournalProteomics
DOIs
Publication statusAccepted/In press - 1 Jan 2019

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Early Detection of Cancer
Colorectal Neoplasms
Biomarkers
Metabolites
Microorganisms
Proteins
Dysbiosis
Gastrointestinal Microbiome
Inflammation
Research

Keywords

  • colorectal cancer
  • gut microbiome
  • mass spectrometry
  • metaproteomics
  • secretome

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

Cite this

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