Analysis of different therapeutic classes using liquid chromatography - mass spectrometry in aquatic environment: A review

Fouad Fadhil Al-Qaim, Md. Pauzi Abdullah, Mohamed Rozali Othman

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Pharmaceuticals included in this review are seventeenth with different therapeutic classes: anti hypertensive (Nifedipine Prazosin HCL Chlorothiazide HCL Enalapril), non steroidal anti inflammatory drugs (Diclofenac Ibuprofen Naproxen Mefenamic acid), antibiotic (Erythromycin), antidiabetic (Metformin Gliclazide), inhabit stomach acid (Ranitidine), simultant (caffeine), harmonal contraception (Levonorgestrel), anticonvulsant (Carbamazepine), bronchodilator (salbutamol), lipid lowering agent (Simvastatin). Large quantities of pharmaceuticals are used today in human and veterinary medicine and many of these pharmaceuticals are excreted without being entirely metabolized in human or animal, so these pharmaceutical residues in aquatic environment are considered sever contaminants. Progress in instrumental analytical chemistry has resulted in the availability of methods that allow a monitoring of these contaminates at ng/L levels. In the current article, a review of the Liquid Chromatography instruments provided with tandem mass, TOF, Q-TOF, Micro Triple Mass and so on, based methods published so far for determination of pharmaceuticals in the aquatic environment is presented. This review also covers the new methodologies to analysis acidic and basic pharmaceuticals; including sample preparation and solid phase extraction are discussed.

Original languageEnglish
Pages (from-to)3-11
Number of pages9
JournalInternational Journal of Pharmacy and Pharmaceutical Sciences
Volume4
Issue number4
Publication statusPublished - 2012

Fingerprint

Liquid Chromatography
Mass Spectrometry
Pharmaceutical Preparations
Therapeutics
Chlorothiazide
Mefenamic Acid
Gliclazide
Levonorgestrel
Naproxen
Enalapril
Ranitidine
Simvastatin
Veterinary Medicine
Albuterol
Diclofenac
Prazosin
Ibuprofen
Metformin
Bronchodilator Agents
Solid Phase Extraction

Keywords

  • Aquatic environment
  • Multi-residue
  • Pharmaceuticals
  • Recovery
  • SPE-LC

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Pharmacology

Cite this

Analysis of different therapeutic classes using liquid chromatography - mass spectrometry in aquatic environment : A review. / Al-Qaim, Fouad Fadhil; Abdullah, Md. Pauzi; Othman, Mohamed Rozali.

In: International Journal of Pharmacy and Pharmaceutical Sciences, Vol. 4, No. 4, 2012, p. 3-11.

Research output: Contribution to journalArticle

@article{168efc91c74845f4b119fb73be7c2acc,
title = "Analysis of different therapeutic classes using liquid chromatography - mass spectrometry in aquatic environment: A review",
abstract = "Pharmaceuticals included in this review are seventeenth with different therapeutic classes: anti hypertensive (Nifedipine Prazosin HCL Chlorothiazide HCL Enalapril), non steroidal anti inflammatory drugs (Diclofenac Ibuprofen Naproxen Mefenamic acid), antibiotic (Erythromycin), antidiabetic (Metformin Gliclazide), inhabit stomach acid (Ranitidine), simultant (caffeine), harmonal contraception (Levonorgestrel), anticonvulsant (Carbamazepine), bronchodilator (salbutamol), lipid lowering agent (Simvastatin). Large quantities of pharmaceuticals are used today in human and veterinary medicine and many of these pharmaceuticals are excreted without being entirely metabolized in human or animal, so these pharmaceutical residues in aquatic environment are considered sever contaminants. Progress in instrumental analytical chemistry has resulted in the availability of methods that allow a monitoring of these contaminates at ng/L levels. In the current article, a review of the Liquid Chromatography instruments provided with tandem mass, TOF, Q-TOF, Micro Triple Mass and so on, based methods published so far for determination of pharmaceuticals in the aquatic environment is presented. This review also covers the new methodologies to analysis acidic and basic pharmaceuticals; including sample preparation and solid phase extraction are discussed.",
keywords = "Aquatic environment, Multi-residue, Pharmaceuticals, Recovery, SPE-LC",
author = "Al-Qaim, {Fouad Fadhil} and Abdullah, {Md. Pauzi} and Othman, {Mohamed Rozali}",
year = "2012",
language = "English",
volume = "4",
pages = "3--11",
journal = "International Journal of Pharmacy and Pharmaceutical Sciences",
issn = "0975-1491",
publisher = "IJPPS",
number = "4",

}

TY - JOUR

T1 - Analysis of different therapeutic classes using liquid chromatography - mass spectrometry in aquatic environment

T2 - A review

AU - Al-Qaim, Fouad Fadhil

AU - Abdullah, Md. Pauzi

AU - Othman, Mohamed Rozali

PY - 2012

Y1 - 2012

N2 - Pharmaceuticals included in this review are seventeenth with different therapeutic classes: anti hypertensive (Nifedipine Prazosin HCL Chlorothiazide HCL Enalapril), non steroidal anti inflammatory drugs (Diclofenac Ibuprofen Naproxen Mefenamic acid), antibiotic (Erythromycin), antidiabetic (Metformin Gliclazide), inhabit stomach acid (Ranitidine), simultant (caffeine), harmonal contraception (Levonorgestrel), anticonvulsant (Carbamazepine), bronchodilator (salbutamol), lipid lowering agent (Simvastatin). Large quantities of pharmaceuticals are used today in human and veterinary medicine and many of these pharmaceuticals are excreted without being entirely metabolized in human or animal, so these pharmaceutical residues in aquatic environment are considered sever contaminants. Progress in instrumental analytical chemistry has resulted in the availability of methods that allow a monitoring of these contaminates at ng/L levels. In the current article, a review of the Liquid Chromatography instruments provided with tandem mass, TOF, Q-TOF, Micro Triple Mass and so on, based methods published so far for determination of pharmaceuticals in the aquatic environment is presented. This review also covers the new methodologies to analysis acidic and basic pharmaceuticals; including sample preparation and solid phase extraction are discussed.

AB - Pharmaceuticals included in this review are seventeenth with different therapeutic classes: anti hypertensive (Nifedipine Prazosin HCL Chlorothiazide HCL Enalapril), non steroidal anti inflammatory drugs (Diclofenac Ibuprofen Naproxen Mefenamic acid), antibiotic (Erythromycin), antidiabetic (Metformin Gliclazide), inhabit stomach acid (Ranitidine), simultant (caffeine), harmonal contraception (Levonorgestrel), anticonvulsant (Carbamazepine), bronchodilator (salbutamol), lipid lowering agent (Simvastatin). Large quantities of pharmaceuticals are used today in human and veterinary medicine and many of these pharmaceuticals are excreted without being entirely metabolized in human or animal, so these pharmaceutical residues in aquatic environment are considered sever contaminants. Progress in instrumental analytical chemistry has resulted in the availability of methods that allow a monitoring of these contaminates at ng/L levels. In the current article, a review of the Liquid Chromatography instruments provided with tandem mass, TOF, Q-TOF, Micro Triple Mass and so on, based methods published so far for determination of pharmaceuticals in the aquatic environment is presented. This review also covers the new methodologies to analysis acidic and basic pharmaceuticals; including sample preparation and solid phase extraction are discussed.

KW - Aquatic environment

KW - Multi-residue

KW - Pharmaceuticals

KW - Recovery

KW - SPE-LC

UR - http://www.scopus.com/inward/record.url?scp=84870886633&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84870886633&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:84870886633

VL - 4

SP - 3

EP - 11

JO - International Journal of Pharmacy and Pharmaceutical Sciences

JF - International Journal of Pharmacy and Pharmaceutical Sciences

SN - 0975-1491

IS - 4

ER -