Analgesic use and chronic renal disease in patients with headache

A. Rahman A. Jamal, M. Segasothy, S. A. Samad, A. Zulfiqar, M. Rani

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

The pattern of analgesic use, abuse and incidence of analgesic-associated nephropathy in 79 patients with chronic headache was studied. Sixty-eight of these patients had migraine. Most patients had consumed a combination of analgesics (81%) while 19% had taken single analgesics for their headache. Nonsteroidal anti-inflammatory drugs were the most commonly used analgesics (96.2%) followed by paracetamol (70.9%) and aspirin, phenacetin and caffeine compounds (5.1%). Mefenamic acid was the commonest nonsteroidal anti- inflammatory drug consumed (97.4%). Analgesic abuse which was defined as a minimum total of 1 kg of analgesics such as paracetamol or aspirin, phenacetin and caffeine compounds or 400 capsules/tablets of nonsteroidal anti-inflammatory drugs was noted in 65 patients. Nonsteroidal anti- inflammatory drugs were the most commonly abused analgesics (89.2%) followed by paracetamol (38.5%). Forty-five of the 65 analgesic abusers had an intravenous urogram or ultrasound performed and renal papillary necrosis was documented in one patient. Three (4.6%) of the analgesic abusers had mildly raised serum creatinine levels. Mild proteinuria of less than 1 gm/litre was present in 27.7% of abusers. In conclusion, although analgesic use and abuse is common in patients with chronic headache, the short term incidence of analgesic-associated nephropathy (2.2%) and renal impairment (4.6%) was low. Prolonged observations will be necessary to ascertain the safety of these drugs for long term use.

Original languageEnglish
Pages (from-to)442-445
Number of pages4
JournalHeadache
Volume33
Issue number8
Publication statusPublished - 1993

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Chronic Renal Insufficiency
Headache
Analgesics
Anti-Inflammatory Agents
Acetaminophen
Headache Disorders
Pharmaceutical Preparations
Mefenamic Acid
Kidney
Urography
Incidence
Migraine Disorders
Proteinuria
Tablets
Capsules
Creatinine
Necrosis
Safety

Keywords

  • analgesic abuse
  • analgesic-associated nephropathy
  • Headache

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

A. Jamal, A. R., Segasothy, M., Samad, S. A., Zulfiqar, A., & Rani, M. (1993). Analgesic use and chronic renal disease in patients with headache. Headache, 33(8), 442-445.

Analgesic use and chronic renal disease in patients with headache. / A. Jamal, A. Rahman; Segasothy, M.; Samad, S. A.; Zulfiqar, A.; Rani, M.

In: Headache, Vol. 33, No. 8, 1993, p. 442-445.

Research output: Contribution to journalArticle

A. Jamal, AR, Segasothy, M, Samad, SA, Zulfiqar, A & Rani, M 1993, 'Analgesic use and chronic renal disease in patients with headache', Headache, vol. 33, no. 8, pp. 442-445.
A. Jamal AR, Segasothy M, Samad SA, Zulfiqar A, Rani M. Analgesic use and chronic renal disease in patients with headache. Headache. 1993;33(8):442-445.
A. Jamal, A. Rahman ; Segasothy, M. ; Samad, S. A. ; Zulfiqar, A. ; Rani, M. / Analgesic use and chronic renal disease in patients with headache. In: Headache. 1993 ; Vol. 33, No. 8. pp. 442-445.
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