An unusual case of aggressive systemic mastocytosis with associated refractory plasma cell myeloma

Preetesh Jain, Srdan Verstovsek, Robert Z. Orlowski, Ernie Yap, Hesham M. Amin

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Systemic mastocytosis with associated clonal hematological non-mast cell lineage disease (SM-AHNMD) is a unique subtype of mast cell neoplasm. In most SMAHNMD cases, it is the myeloid malignancy that accompanies systemic mastocytosis (SM), and cases of associated chronic lymphoproliferative neoplasm or plasma cell dyscrasia are relatively infrequent. Concurrent clinical presentation of SM with aggressive refractory plasma cell myeloma is a very rare entity. We documented CD30 expression on the neoplastic mast cells in the bone marrow biopsy specimen from a patient. It has been reported that neoplastic mast cells can express CD30 ligand, which enhances their growth and is associated with aggressive SM. This finding could have therapeutic implications for the treatment of SM with anti-CD30 monoclonal antibody.

Original languageEnglish
Pages (from-to)459-462
Number of pages4
JournalClinical Lymphoma, Myeloma and Leukemia
Volume12
Issue number6
DOIs
Publication statusPublished - 1 Dec 2012
Externally publishedYes

Fingerprint

Systemic Mastocytosis
Multiple Myeloma
Mast Cells
CD30 Ligand
Neoplasms
Paraproteinemias
Cell Lineage
Bone Marrow
Monoclonal Antibodies
Biopsy
Therapeutics
Growth

Keywords

  • Plasma cell neoplasms
  • SM-AHNMD
  • Systemic mastocytosis

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

Cite this

An unusual case of aggressive systemic mastocytosis with associated refractory plasma cell myeloma. / Jain, Preetesh; Verstovsek, Srdan; Orlowski, Robert Z.; Yap, Ernie; Amin, Hesham M.

In: Clinical Lymphoma, Myeloma and Leukemia, Vol. 12, No. 6, 01.12.2012, p. 459-462.

Research output: Contribution to journalArticle

Jain, Preetesh ; Verstovsek, Srdan ; Orlowski, Robert Z. ; Yap, Ernie ; Amin, Hesham M. / An unusual case of aggressive systemic mastocytosis with associated refractory plasma cell myeloma. In: Clinical Lymphoma, Myeloma and Leukemia. 2012 ; Vol. 12, No. 6. pp. 459-462.
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