An oxepinoflavone from Artocarpus elasticus with cytotoxic activity against P-388 cells

Iqbal Musthapa, Lia D. Juliawaty, Yana M. Syah, Euis H. Hakim, Jalifah Latip, Emilio L. Ghisalberti

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

A new oxepinoflavone, artoindonesianin E1 (1), was isolated from the wood of Artocarpus elasticus, along with four known prenylated flavones: artocarpin (2), cycloartocarpin (3), cudraflavones A (4) and C (5). The structure of the new compound was identified by spectroscopic methods. Upon cytotoxic evaluation against murine leukemia P-388 cells, the new compound showed IC50 5.0 μg/mL.

Original languageEnglish
Pages (from-to)191-194
Number of pages4
JournalArchives of Pharmacal Research
Volume32
Issue number2
DOIs
Publication statusPublished - Feb 2009

Fingerprint

Artocarpus
Flavones
Inhibitory Concentration 50
Wood
Leukemia
artocarpin lectin
artoindonesianin E1

Keywords

  • Artocarpus elasticus
  • Artoindonesianin E1
  • Cytotoxicity
  • Flavonoids
  • Oxepinoflavone
  • P-388 cells

ASJC Scopus subject areas

  • Drug Discovery
  • Molecular Medicine
  • Organic Chemistry

Cite this

An oxepinoflavone from Artocarpus elasticus with cytotoxic activity against P-388 cells. / Musthapa, Iqbal; Juliawaty, Lia D.; Syah, Yana M.; Hakim, Euis H.; Latip, Jalifah; Ghisalberti, Emilio L.

In: Archives of Pharmacal Research, Vol. 32, No. 2, 02.2009, p. 191-194.

Research output: Contribution to journalArticle

Musthapa, Iqbal ; Juliawaty, Lia D. ; Syah, Yana M. ; Hakim, Euis H. ; Latip, Jalifah ; Ghisalberti, Emilio L. / An oxepinoflavone from Artocarpus elasticus with cytotoxic activity against P-388 cells. In: Archives of Pharmacal Research. 2009 ; Vol. 32, No. 2. pp. 191-194.
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