An overview of structure-Activity relationship studies of curcumin analogs as antioxidant and anti-inflammatory agents

Laiba Arshad, Md Areeful Haque, Bukhari Syed Nasir Abbas, Ibrahim Jantan

Research output: Contribution to journalReview article

18 Citations (Scopus)

Abstract

Curcumin, extracted mainly from Curcuma longa rhizomes, has been reported to possess potent anti-inflammatory and anti-oxidant activities. Although safe at higher doses and exhibiting multiple biological activities, curcumin still has the problem of poor bioavailability which has been an attractive area of research over the last few years. A number of efforts have been made by modifying structural features of curcumin. This review highlights the structurally modified and more stable newly synthesized curcumin analogs that have been screened against antioxidant and anti-inflammatory activities. Also the structure-Activity relationship to gain insight into future guidelines for scheming new compounds has been discussed, and further these analogs being more stable may serve as promising agents for use in different pathological conditions.

Original languageEnglish
Pages (from-to)605-626
Number of pages22
JournalFuture Medicinal Chemistry
Volume9
Issue number6
DOIs
Publication statusPublished - 1 Apr 2017

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Curcumin
Structure-Activity Relationship
Anti-Inflammatory Agents
Antioxidants
Curcuma
Rhizome
Oxidants
Biological Availability
Guidelines
Research

Keywords

  • anti-inflammatory
  • antioxidant
  • curcumin analogs
  • structure-Activity relationship

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology
  • Drug Discovery

Cite this

An overview of structure-Activity relationship studies of curcumin analogs as antioxidant and anti-inflammatory agents. / Arshad, Laiba; Areeful Haque, Md; Syed Nasir Abbas, Bukhari; Jantan, Ibrahim.

In: Future Medicinal Chemistry, Vol. 9, No. 6, 01.04.2017, p. 605-626.

Research output: Contribution to journalReview article

Arshad, Laiba ; Areeful Haque, Md ; Syed Nasir Abbas, Bukhari ; Jantan, Ibrahim. / An overview of structure-Activity relationship studies of curcumin analogs as antioxidant and anti-inflammatory agents. In: Future Medicinal Chemistry. 2017 ; Vol. 9, No. 6. pp. 605-626.
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