An interesting case of systemic lupus erythematosus presenting with hypercalcemia

A diagnostic dilemma

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1 Citation (Scopus)

Abstract

Background: Hypercalcemia is common in primary hyperparathyroidism malignancies and even in tuberculosis. Interestingly, systemic lupus erythematosus (SLE) rarely presents with hypercalcemia. Case Report: We describe an interesting case of SLE in a patient who was otherwise thought to have either tuberculosis or a malignancy. The patient initially presented with feeling unwell, with generalized lymphadenopathy, bilater- al pleural effusion, and bilateral corneal calcium deposits secondary to severe hypercalcemia. The diagnosis of SLE was made based on positivity of antinuclear antibodies (ANA) and anti-dsDNA, the presence of serositis, lymphadenopathy, autoimmune hemolytic anemia, and constitutional symptoms. She was treated with ste- roids, with tremendous improvement in her general well-being, resolution of lymphadenopathy and pleural ef- fusion, and normalization of her hemoglobin and serum calcium. The atypical presentation of SLE with hyper- calcemia with pleural effusion is discussed.Conclusions: SLE should be one of the differential diagnoses in patients presenting with severe hypercalcemia.

Original languageEnglish
Pages (from-to)83-85
Number of pages3
JournalAmerican Journal of Case Reports
Volume14
DOIs
Publication statusPublished - 25 Mar 2013

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Hypercalcemia
Systemic Lupus Erythematosus
Pleural Effusion
Tuberculosis
Serositis
Calcium
Autoimmune Hemolytic Anemia
Primary Hyperparathyroidism
Antinuclear Antibodies
Neoplasms
Emotions
Hemoglobins
Differential Diagnosis
Steroids
Serum
Lymphadenopathy

Keywords

  • Atypical presentation
  • Hypercalcemia
  • Systemic lupus erythematosus

ASJC Scopus subject areas

  • Medicine(all)

Cite this

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title = "An interesting case of systemic lupus erythematosus presenting with hypercalcemia: A diagnostic dilemma",
abstract = "Background: Hypercalcemia is common in primary hyperparathyroidism malignancies and even in tuberculosis. Interestingly, systemic lupus erythematosus (SLE) rarely presents with hypercalcemia. Case Report: We describe an interesting case of SLE in a patient who was otherwise thought to have either tuberculosis or a malignancy. The patient initially presented with feeling unwell, with generalized lymphadenopathy, bilater- al pleural effusion, and bilateral corneal calcium deposits secondary to severe hypercalcemia. The diagnosis of SLE was made based on positivity of antinuclear antibodies (ANA) and anti-dsDNA, the presence of serositis, lymphadenopathy, autoimmune hemolytic anemia, and constitutional symptoms. She was treated with ste- roids, with tremendous improvement in her general well-being, resolution of lymphadenopathy and pleural ef- fusion, and normalization of her hemoglobin and serum calcium. The atypical presentation of SLE with hyper- calcemia with pleural effusion is discussed.Conclusions: SLE should be one of the differential diagnoses in patients presenting with severe hypercalcemia.",
keywords = "Atypical presentation, Hypercalcemia, Systemic lupus erythematosus",
author = "{Abdul Gafor}, {Abdul Halim} and {Abdul Cader}, Rizna and Srijit Das and Noraidah Masir and {S. Abdul Wahid}, {S Fadilah}",
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T1 - An interesting case of systemic lupus erythematosus presenting with hypercalcemia

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AU - Abdul Gafor, Abdul Halim

AU - Abdul Cader, Rizna

AU - Das, Srijit

AU - Masir, Noraidah

AU - S. Abdul Wahid, S Fadilah

PY - 2013/3/25

Y1 - 2013/3/25

N2 - Background: Hypercalcemia is common in primary hyperparathyroidism malignancies and even in tuberculosis. Interestingly, systemic lupus erythematosus (SLE) rarely presents with hypercalcemia. Case Report: We describe an interesting case of SLE in a patient who was otherwise thought to have either tuberculosis or a malignancy. The patient initially presented with feeling unwell, with generalized lymphadenopathy, bilater- al pleural effusion, and bilateral corneal calcium deposits secondary to severe hypercalcemia. The diagnosis of SLE was made based on positivity of antinuclear antibodies (ANA) and anti-dsDNA, the presence of serositis, lymphadenopathy, autoimmune hemolytic anemia, and constitutional symptoms. She was treated with ste- roids, with tremendous improvement in her general well-being, resolution of lymphadenopathy and pleural ef- fusion, and normalization of her hemoglobin and serum calcium. The atypical presentation of SLE with hyper- calcemia with pleural effusion is discussed.Conclusions: SLE should be one of the differential diagnoses in patients presenting with severe hypercalcemia.

AB - Background: Hypercalcemia is common in primary hyperparathyroidism malignancies and even in tuberculosis. Interestingly, systemic lupus erythematosus (SLE) rarely presents with hypercalcemia. Case Report: We describe an interesting case of SLE in a patient who was otherwise thought to have either tuberculosis or a malignancy. The patient initially presented with feeling unwell, with generalized lymphadenopathy, bilater- al pleural effusion, and bilateral corneal calcium deposits secondary to severe hypercalcemia. The diagnosis of SLE was made based on positivity of antinuclear antibodies (ANA) and anti-dsDNA, the presence of serositis, lymphadenopathy, autoimmune hemolytic anemia, and constitutional symptoms. She was treated with ste- roids, with tremendous improvement in her general well-being, resolution of lymphadenopathy and pleural ef- fusion, and normalization of her hemoglobin and serum calcium. The atypical presentation of SLE with hyper- calcemia with pleural effusion is discussed.Conclusions: SLE should be one of the differential diagnoses in patients presenting with severe hypercalcemia.

KW - Atypical presentation

KW - Hypercalcemia

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