An evaluation of sulforaphane as a potential agent for disease prevention

Nadia Salem Alrawaiq, Azman Abdullah

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

This research examines sulforaphane (SFN), a phytochemical element that is found in certain plants and vegetables. SFN has particular biological behaviours and roles to combat many diseases. It can be found mainly in vegetables such as Brussels sprouts, kale, cauliflower, and broccoli. SFN is a nutritional isothiocyanate compound and is known as a glucosinolate precursor. It is reputed to have valuable pharmacological properties, namely antioxidant, anti-inflammatory, and antitumor properties, and also functions as an agent of defence against diabetes, ocular disorders and cardiovascular diseases as well as for neurodegenerative disease. It also efficiently searches out and feeds on ROS (reactive oxygen species). Sulforaphane is a potential antioxidant for relieving oxidative stress and reducing tissue/cell damage in various in vivo and in vitro experimental models. The results of this research confirm that the natural compound, SFN, has several protective properties and that the nuclear factor, erythroid-2-related factor 2 system, which facilitates the expression of several antioxidant genes, plays a crucial role in the protective effect of such isothiocyanates against practically all the medical conditions mentioned above. The findings of this study serve to provide a more in-depth understanding of the nature of SFN and its functions, thus adding to the existing literature and research on the subject.

Original languageEnglish
Pages (from-to)1335-1349
Number of pages15
JournalResearch Journal of Pharmaceutical, Biological and Chemical Sciences
Volume5
Issue number3
Publication statusPublished - 2014

Fingerprint

Brassica
Antioxidants
Vegetables
Research
Isothiocyanates
Neurodegenerative diseases
Glucosinolates
Oxidative stress
Eye Diseases
Phytochemicals
Medical problems
Neurodegenerative Diseases
sulforafan
Reactive Oxygen Species
Oxidative Stress
Anti-Inflammatory Agents
Theoretical Models
Cardiovascular Diseases
Genes
Cells

Keywords

  • Nrf2
  • Phase 2 detoxifying enzymes
  • Sulforaphane

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

An evaluation of sulforaphane as a potential agent for disease prevention. / Alrawaiq, Nadia Salem; Abdullah, Azman.

In: Research Journal of Pharmaceutical, Biological and Chemical Sciences, Vol. 5, No. 3, 2014, p. 1335-1349.

Research output: Contribution to journalArticle

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