An assessment of the acetone extract from the leaves of Canarium odontophyllum (Miq.) for antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA)

Nur Amira Mohd Shamsuddin, Noraziah Mohamad Zin, Dayang Fredalina Basri

Research output: Contribution to journalArticle

Abstract

Methicillin-resistant Staphylococcus aureus (MRSA) causes nosocomial and community infections and is a global health concern. This study evaluated the antibacterial activity of acetone extract from Canarium odontophyllum leaves against MRSA ATCC 33591 and Mu50 strains. The MIC/MBC ratio, determined using the broth micro dilution method, revealed the bacteriostatic effect of the extract against both strains. Time-kill assay against the Mu50 strain showed that the extract inhibited the growth of MRSA at low concentration but exhibited a concentration-dependent bacterial killing effect at 4× MIC. These findings confirm that an acetone extract from C. odontophyllum leaves inhibited growth of MRSA at low concentrations and could be utilised as an alternative anti-MRSA agent.

Original languageEnglish
Pages (from-to)601-605
Number of pages5
JournalMalaysian Journal of Microbiology
Volume14
Issue numberSpecialissue6
DOIs
Publication statusPublished - 1 Jan 2018

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Methicillin-Resistant Staphylococcus aureus
Acetone
Growth
Cross Infection

Keywords

  • Bacteriostatic
  • C. odontophyllum
  • MBC
  • MIC
  • MRSA

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

Cite this

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AB - Methicillin-resistant Staphylococcus aureus (MRSA) causes nosocomial and community infections and is a global health concern. This study evaluated the antibacterial activity of acetone extract from Canarium odontophyllum leaves against MRSA ATCC 33591 and Mu50 strains. The MIC/MBC ratio, determined using the broth micro dilution method, revealed the bacteriostatic effect of the extract against both strains. Time-kill assay against the Mu50 strain showed that the extract inhibited the growth of MRSA at low concentration but exhibited a concentration-dependent bacterial killing effect at 4× MIC. These findings confirm that an acetone extract from C. odontophyllum leaves inhibited growth of MRSA at low concentrations and could be utilised as an alternative anti-MRSA agent.

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