An alarmingly high prevalence of diabetic nephropathy in Asian type 2 diabetic patients: The MicroAlbuminuria Prevalence (MAP) Study

A. Y T Wu, N. C T Kong, F. A. De Leon, C. Y. Pan, T. Y. Tai, V. T F Yeung, S. J. Yoo, A. Rouillon, M. R. Weir

    Research output: Contribution to journalArticle

    148 Citations (Scopus)

    Abstract

    Aim/hypothesis: Microalbuminuria represents the earliest clinical evidence of diabetic nephropathy and is a marker of increased cardiovascular morbidity and mortality. Its early detection allows the implementation of individualised and aggressive intervention programmes to reduce cardiovascular risk factors. There is limited information on the prevalence of microalbuminuria among hypertensive type 2 diabetic patients in Asia. Methods: This cross-sectional epidemiological study aimed to assess the prevalence of microalbuminuria and macroalbuminuria among consecutively screened hypertensive type 2 diabetic adult patients in 103 centres in 10 Asian countries or regions. Predictive factors for microalbuminuria and macroalbuminuria were characterised using a stepwise logistic regression model. Results: A total of 6,801 patients were enrolled and 5,549 patients constituted the per-protocol population (patients with bacteriuria and haematuria were excluded). The prevalence of microalbuminuria was 39.8% (39.2-40.5; 95% CI) and the prevalence of macroalbuminuria was 18.8% (18.2-19.3; 95% CI). Only 11.6% of the patients had systolic and diastolic blood pressure below the 130/80 mm Hg target. In the multivariate analyses, the predictive factors for the presence of microalbuminuria were age, BMI, systolic blood pressure and ethnic origin. The highlighted predictive factors for the presence of macroalbuminuria were age, sex, ethnic origin, BMI, duration of diabetes, presence of diabetic complications, intake of diuretics, intake of calcium channel blockers, diastolic and systolic blood pressure. Conclusions/interpretation: The high prevalence (58.6%) of micro or macroalbuminuria observed in these patients is alarming and indicates an impending pandemic of diabetic cardiovascular and renal diseases in Asia with its potential economic consequences.

    Original languageEnglish
    Pages (from-to)17-26
    Number of pages10
    JournalDiabetologia
    Volume48
    Issue number1
    DOIs
    Publication statusPublished - Jan 2005

    Fingerprint

    Diabetic Nephropathies
    Cross-Sectional Studies
    Blood Pressure
    Logistic Models
    Bacteriuria
    Calcium Channel Blockers
    Pandemics
    Hematuria
    Diabetes Complications
    Diuretics
    Epidemiologic Studies
    Cardiovascular Diseases
    Multivariate Analysis
    Economics
    Morbidity
    Kidney
    Mortality
    Population

    Keywords

    • Asia
    • Diabetic nephropathy
    • Hypertension
    • Macroalbuminuria
    • Microalbuminuria
    • Prevalence

    ASJC Scopus subject areas

    • Internal Medicine
    • Endocrinology, Diabetes and Metabolism

    Cite this

    Wu, A. Y. T., Kong, N. C. T., De Leon, F. A., Pan, C. Y., Tai, T. Y., Yeung, V. T. F., ... Weir, M. R. (2005). An alarmingly high prevalence of diabetic nephropathy in Asian type 2 diabetic patients: The MicroAlbuminuria Prevalence (MAP) Study. Diabetologia, 48(1), 17-26. https://doi.org/10.1007/s00125-004-1599-9

    An alarmingly high prevalence of diabetic nephropathy in Asian type 2 diabetic patients : The MicroAlbuminuria Prevalence (MAP) Study. / Wu, A. Y T; Kong, N. C T; De Leon, F. A.; Pan, C. Y.; Tai, T. Y.; Yeung, V. T F; Yoo, S. J.; Rouillon, A.; Weir, M. R.

    In: Diabetologia, Vol. 48, No. 1, 01.2005, p. 17-26.

    Research output: Contribution to journalArticle

    Wu, AYT, Kong, NCT, De Leon, FA, Pan, CY, Tai, TY, Yeung, VTF, Yoo, SJ, Rouillon, A & Weir, MR 2005, 'An alarmingly high prevalence of diabetic nephropathy in Asian type 2 diabetic patients: The MicroAlbuminuria Prevalence (MAP) Study', Diabetologia, vol. 48, no. 1, pp. 17-26. https://doi.org/10.1007/s00125-004-1599-9
    Wu, A. Y T ; Kong, N. C T ; De Leon, F. A. ; Pan, C. Y. ; Tai, T. Y. ; Yeung, V. T F ; Yoo, S. J. ; Rouillon, A. ; Weir, M. R. / An alarmingly high prevalence of diabetic nephropathy in Asian type 2 diabetic patients : The MicroAlbuminuria Prevalence (MAP) Study. In: Diabetologia. 2005 ; Vol. 48, No. 1. pp. 17-26.
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    abstract = "Aim/hypothesis: Microalbuminuria represents the earliest clinical evidence of diabetic nephropathy and is a marker of increased cardiovascular morbidity and mortality. Its early detection allows the implementation of individualised and aggressive intervention programmes to reduce cardiovascular risk factors. There is limited information on the prevalence of microalbuminuria among hypertensive type 2 diabetic patients in Asia. Methods: This cross-sectional epidemiological study aimed to assess the prevalence of microalbuminuria and macroalbuminuria among consecutively screened hypertensive type 2 diabetic adult patients in 103 centres in 10 Asian countries or regions. Predictive factors for microalbuminuria and macroalbuminuria were characterised using a stepwise logistic regression model. Results: A total of 6,801 patients were enrolled and 5,549 patients constituted the per-protocol population (patients with bacteriuria and haematuria were excluded). The prevalence of microalbuminuria was 39.8{\%} (39.2-40.5; 95{\%} CI) and the prevalence of macroalbuminuria was 18.8{\%} (18.2-19.3; 95{\%} CI). Only 11.6{\%} of the patients had systolic and diastolic blood pressure below the 130/80 mm Hg target. In the multivariate analyses, the predictive factors for the presence of microalbuminuria were age, BMI, systolic blood pressure and ethnic origin. The highlighted predictive factors for the presence of macroalbuminuria were age, sex, ethnic origin, BMI, duration of diabetes, presence of diabetic complications, intake of diuretics, intake of calcium channel blockers, diastolic and systolic blood pressure. Conclusions/interpretation: The high prevalence (58.6{\%}) of micro or macroalbuminuria observed in these patients is alarming and indicates an impending pandemic of diabetic cardiovascular and renal diseases in Asia with its potential economic consequences.",
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    T2 - The MicroAlbuminuria Prevalence (MAP) Study

    AU - Wu, A. Y T

    AU - Kong, N. C T

    AU - De Leon, F. A.

    AU - Pan, C. Y.

    AU - Tai, T. Y.

    AU - Yeung, V. T F

    AU - Yoo, S. J.

    AU - Rouillon, A.

    AU - Weir, M. R.

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    KW - Diabetic nephropathy

    KW - Hypertension

    KW - Macroalbuminuria

    KW - Microalbuminuria

    KW - Prevalence

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