Ameliorative effect of Moringa oleifera fruit extract on reproductive parameters in diabetic-induced male rats

Amira Kamalrudin, Malina Jasamai, Mahanem Mat Noor

Research output: Contribution to journalArticle

Abstract

Background: Diabetes mellitus negatively impact the male reproductive parameters. The ability of Moringa oleifera fruit to improve the reproductive parameters in diabetic-induced male has yet to be documented. Aim: To investigate the anti-hyperglycaemic potential of M. oleifera fruit aqueous extract and its effect on reproductive parameters in diabetic-induced male rats. Materials and Methods: A total of 20 male Sprague Dawley rats were divided into four groups; normal control (without diabetic induction), negative control (diabetes without treatment), positive control (diabetes with metformin) and treatment group (diabetes with 500 mg/kg M. oleifera fruit aqueous extract). Treatments were given via oral gavage for 21 consecutive days. Analysis of fasting blood glucose level, sperm quality, testicular histology and relative testis weight were performed. Results: The administration of M. oleifera fruit aqueous extract exhibited a significant reduction in fasting blood glucose level and a pronounced increase in sperm quality (sperm count, motility, viability and morphology) compared with the negative control group. M. oleifera fruit extract restored the histology of the testes as they were seen to be packed with sperms and showed an organised spermatogenesis. The relative testis weight showed no significant difference between all groups. Conclusion: The results obtained suggested that M. oleifera fruit aqueous extract possessed an antihyperglycaemic property and improved the reproductive parameters in diabetic-induced rats.

Original languageEnglish
Pages (from-to)S54-S58
JournalPharmacognosy Journal
Volume10
Issue number6
DOIs
Publication statusPublished - 1 Jan 2018

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Moringa oleifera
Fruit
Spermatozoa
Testis
Blood Glucose
Fasting
Histology
Weights and Measures
Aptitude
Sperm Count
Sperm Motility
Metformin
Spermatogenesis
Hypoglycemic Agents
Sprague Dawley Rats
Diabetes Mellitus
Therapeutics
Control Groups

Keywords

  • Diabetes mellitus
  • Fasting blood glucose level
  • Male reproductive
  • Moringa oleifera fruit
  • Sperm quality

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

Cite this

Ameliorative effect of Moringa oleifera fruit extract on reproductive parameters in diabetic-induced male rats. / Kamalrudin, Amira; Jasamai, Malina; Mat Noor, Mahanem.

In: Pharmacognosy Journal, Vol. 10, No. 6, 01.01.2018, p. S54-S58.

Research output: Contribution to journalArticle

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