Alpha lipoic acid prevents pancreatic islet cells damage and dyslipidemia in streptozotocin-induced diabetic rats

Siti Balkis Budin, Kwa Poi Kee, Monica Yau Swee Eng, Khairul Osman, Mokhtar Abu Bakar, Jamaludin Mohamed

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

In the present study, the effects of alpha lipoic acid (ALA) supplementation on glycemic control and lipid profile in streptozotocin (STZ)-induced diabetic rats have been evaluated. Sprague Dawley rats were divided into nondiabetic (NDM), diabetic without supplementation (No Suppl) and diabetic with ALA groups. ALA was orally administered once a day for 8 weeks with a dose of 100 mg/kg BW. Supplementation of ALA to STZ-induced rats prevented the severe damage to the islet cells of the pancreas and lowered the plasma glucose and glycated hemoglobin (HbA1c) levels. Supplementation of ALA also suppressed the increased of total cholesterol (TC), triglycerides and low density lipoprotein-cholesterol (LDL-C) levels in the plasma of diabetic rats as well as increased high density lipoprotein-cholesterol (HDL-C) levels. In conclusion, this study suggest that ALA may be effective in controlling glycemic status and improving dyslipidemia in streptozotocin-induced diabetic rats and has the potential in reducing cardiovascular complications due to diabetes mellitus.

Original languageEnglish
Pages (from-to)47-53
Number of pages7
JournalMalaysian Journal of Medical Sciences
Volume14
Issue number2
Publication statusPublished - Jul 2007

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Thioctic Acid
Streptozocin
Dyslipidemias
Islets of Langerhans
Glycosylated Hemoglobin A
LDL Cholesterol
HDL Cholesterol
Sprague Dawley Rats
Pancreas
Diabetes Mellitus
Triglycerides
Cholesterol
Lipids
Glucose

Keywords

  • Alpha lipoic acid
  • Diabetes mellitus
  • Dyslipidemia
  • Hyperglycemia
  • Islet cells

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Alpha lipoic acid prevents pancreatic islet cells damage and dyslipidemia in streptozotocin-induced diabetic rats. / Budin, Siti Balkis; Kee, Kwa Poi; Eng, Monica Yau Swee; Osman, Khairul; Bakar, Mokhtar Abu; Mohamed, Jamaludin.

In: Malaysian Journal of Medical Sciences, Vol. 14, No. 2, 07.2007, p. 47-53.

Research output: Contribution to journalArticle

Budin, Siti Balkis ; Kee, Kwa Poi ; Eng, Monica Yau Swee ; Osman, Khairul ; Bakar, Mokhtar Abu ; Mohamed, Jamaludin. / Alpha lipoic acid prevents pancreatic islet cells damage and dyslipidemia in streptozotocin-induced diabetic rats. In: Malaysian Journal of Medical Sciences. 2007 ; Vol. 14, No. 2. pp. 47-53.
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