Allergic phenotype of chronic rhinosinusitis based on radiologic pattern of disease

Aneeza Khairiyah Wan Hamizan, Patricia A. Loftus, Raquel Alvarado, Jacqueline Ho, Larry Kalish, Raymond Sacks, John M. Delgaudio, Richard J. Harvey

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Objectives/Hypothesis: Polypoid edema of the middle turbinate is a marker of inhalant allergy. Extensive edematous changes may result in limited central nasal and sinus disease, which has been called central compartment atopic disease (CCAD). Radiologically, this is seen as soft tissue thickening in the central portion of the sinonasal cavity with or without paranasal sinus involvement. When the sinuses are involved, the soft tissue thickening spares the sinus roof or lateral wall (centrally limited). This centrally limited radiological pattern was assessed among chronic rhinosinusitis (CRS) patients and compared to allergy status. Study Design: Diagnostic cross-sectional study. Methods: This study included consecutive CRS patients without prior sinus surgery. Computed tomography (CT) scans of the paranasal sinuses were blindly assessed and allergy status was confirmed by serum or skin testing. Individual sinus cavities were defined as either centrally limited or diffuse disease. The radiological pattern that may predict allergy was determined, and its diagnostic accuracy was calculated. Results: One hundred twelve patients diagnosed to have CRS, representing 224 sides, were assessed (age 46.31±13.57 years, 38.39% female, 41.07% asthma, Lund-Mackay CT score 15.88±4.35, 56.25% atopic). The radiological pattern defined by centrally limited changes in all of the paranasal sinuses was associated with allergy status (73.53% vs. 53.16%, P=.03). This predicted atopy with 90.82% specificity, 73.53% positive predictive value, likelihood positive ratios of 2.16, and diagnostic odds ratio of 4.59. Conclusions: A central radiological pattern of mucosal disease is associated with inhalant allergen sensitization. This group may represent a CCAD subgroup of patients with mainly allergic etiology.

Original languageEnglish
JournalLaryngoscope
DOIs
Publication statusAccepted/In press - 1 Jan 2018

Fingerprint

Paranasal Sinuses
Hypersensitivity
Phenotype
Tomography
Nose Diseases
Turbinates
Allergens
Edema
Asthma
Cross-Sectional Studies
Odds Ratio
Skin
Serum

Keywords

  • Aeroallergens
  • Allergic rhinitis
  • Chronic rhinosinusitis
  • Computed tomography
  • Paranasal sinuses

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Wan Hamizan, A. K., Loftus, P. A., Alvarado, R., Ho, J., Kalish, L., Sacks, R., ... Harvey, R. J. (Accepted/In press). Allergic phenotype of chronic rhinosinusitis based on radiologic pattern of disease. Laryngoscope. https://doi.org/10.1002/lary.27180

Allergic phenotype of chronic rhinosinusitis based on radiologic pattern of disease. / Wan Hamizan, Aneeza Khairiyah; Loftus, Patricia A.; Alvarado, Raquel; Ho, Jacqueline; Kalish, Larry; Sacks, Raymond; Delgaudio, John M.; Harvey, Richard J.

In: Laryngoscope, 01.01.2018.

Research output: Contribution to journalArticle

Wan Hamizan, Aneeza Khairiyah ; Loftus, Patricia A. ; Alvarado, Raquel ; Ho, Jacqueline ; Kalish, Larry ; Sacks, Raymond ; Delgaudio, John M. ; Harvey, Richard J. / Allergic phenotype of chronic rhinosinusitis based on radiologic pattern of disease. In: Laryngoscope. 2018.
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abstract = "Objectives/Hypothesis: Polypoid edema of the middle turbinate is a marker of inhalant allergy. Extensive edematous changes may result in limited central nasal and sinus disease, which has been called central compartment atopic disease (CCAD). Radiologically, this is seen as soft tissue thickening in the central portion of the sinonasal cavity with or without paranasal sinus involvement. When the sinuses are involved, the soft tissue thickening spares the sinus roof or lateral wall (centrally limited). This centrally limited radiological pattern was assessed among chronic rhinosinusitis (CRS) patients and compared to allergy status. Study Design: Diagnostic cross-sectional study. Methods: This study included consecutive CRS patients without prior sinus surgery. Computed tomography (CT) scans of the paranasal sinuses were blindly assessed and allergy status was confirmed by serum or skin testing. Individual sinus cavities were defined as either centrally limited or diffuse disease. The radiological pattern that may predict allergy was determined, and its diagnostic accuracy was calculated. Results: One hundred twelve patients diagnosed to have CRS, representing 224 sides, were assessed (age 46.31±13.57 years, 38.39{\%} female, 41.07{\%} asthma, Lund-Mackay CT score 15.88±4.35, 56.25{\%} atopic). The radiological pattern defined by centrally limited changes in all of the paranasal sinuses was associated with allergy status (73.53{\%} vs. 53.16{\%}, P=.03). This predicted atopy with 90.82{\%} specificity, 73.53{\%} positive predictive value, likelihood positive ratios of 2.16, and diagnostic odds ratio of 4.59. Conclusions: A central radiological pattern of mucosal disease is associated with inhalant allergen sensitization. This group may represent a CCAD subgroup of patients with mainly allergic etiology.",
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AU - Ho, Jacqueline

AU - Kalish, Larry

AU - Sacks, Raymond

AU - Delgaudio, John M.

AU - Harvey, Richard J.

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KW - Computed tomography

KW - Paranasal sinuses

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