All elevated creatine kinase is not neuroleptic malignant syndrome.

T. Maniam, M. A. Rahman

    Research output: Contribution to journalArticle

    4 Citations (Scopus)

    Abstract

    Creatine kinase (CK) is an enzyme that is found widely in muscle tissues. Raised levels would occur when there is muscle damage. Raised levels are used as one of the diagnostic criteria for Neuroleptic Malignant Syndrome (NMS). This study looks at CK levels in 30 psychotic inpatients without NMS and compares them with 10 patients with NMS. It was found that 67% of the patients without NMS had raised CK levels, 20% of whom had levels in excess of 1000 IU/L. The rest had a two to five-fold increase over normal limits. Raised levels were associated with the use of intramuscular injections and physical restraints, situations which are well known to result in muscle injury. All the NMS patients had raised CK levels but 40% had levels below 1000 IU/L. Our findings support the idea that CK levels, though helpful, should be interpreted with care as raised levels are nonspecific.

    Original languageEnglish
    Pages (from-to)252-254
    Number of pages3
    JournalMedical Journal of Malaysia
    Volume49
    Issue number3
    Publication statusPublished - Sep 1994

    Fingerprint

    Neuroleptic Malignant Syndrome
    Creatine Kinase
    Muscles
    Physical Restraint
    Intramuscular Injections
    Inpatients
    Wounds and Injuries
    Enzymes

    ASJC Scopus subject areas

    • Medicine(all)

    Cite this

    All elevated creatine kinase is not neuroleptic malignant syndrome. / Maniam, T.; Rahman, M. A.

    In: Medical Journal of Malaysia, Vol. 49, No. 3, 09.1994, p. 252-254.

    Research output: Contribution to journalArticle

    Maniam, T & Rahman, MA 1994, 'All elevated creatine kinase is not neuroleptic malignant syndrome.', Medical Journal of Malaysia, vol. 49, no. 3, pp. 252-254.
    Maniam, T. ; Rahman, M. A. / All elevated creatine kinase is not neuroleptic malignant syndrome. In: Medical Journal of Malaysia. 1994 ; Vol. 49, No. 3. pp. 252-254.
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