Aggressive variant large granular lymphocytic leukaemia

A case report

M. N. Sabariah, S. Zainina, I. Faridah, Leong Chooi Fun

Research output: Contribution to journalArticle

Abstract

Clonal disorders of LGL may either be CD3+ CD56- or CD3- CD56+ phenotype and these have been designated as T-cell leukaemia (T-LGL) or natural killer cell (NK)-LGL leukaemia respectively. Clonality is usually demonstrated by clonal rearrangement of T-cell receptor gene rearrangement or identified by flowcytometry analysis. Most patients with T-LGL will have an indolent course. In this report we described an aggressiveness of disease in a patient with clonal CD3+ LGL leukaemia whose cells also co-expressed CD56 diagnosed by flowcytometry. The patient responded well to interrupt ALL standard risk protocol however succumbed to her disease while waiting for upfront stem cell transplant. This case highlights on both the classical laboratory findings of rare entity of disease as well as a review of the literature pertaining particularly on its management.

Original languageEnglish
Pages (from-to)57-60
Number of pages4
JournalMalaysian Journal of Medicine and Health Sciences
Volume7
Issue number1
Publication statusPublished - Jan 2011

Fingerprint

Large Granular Lymphocytic Leukemia
T-Lymphocyte Gene Rearrangement
T-Cell Leukemia
T-Cell Receptor Genes
Rare Diseases
Natural Killer Cells
Stem Cells
Transplants
Phenotype

Keywords

  • NK leukaemia
  • T-LGL
  • Treatment of aggressive

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Aggressive variant large granular lymphocytic leukaemia : A case report. / Sabariah, M. N.; Zainina, S.; Faridah, I.; Chooi Fun, Leong.

In: Malaysian Journal of Medicine and Health Sciences, Vol. 7, No. 1, 01.2011, p. 57-60.

Research output: Contribution to journalArticle

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