Age-related rarefaction in retinal vasculature is not linear

M. Z. Che Azemin, F. Ab Hamid, Amilia Aminuddin, J. J. Wang, R. Kawasaki, D. K. Kumar

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The fractal dimension is a global measure of complexity and is useful for quantifying anatomical structures, including the retinal vascular network. A previous study found a linear declining trend with aging on the retinal vascular fractal dimension (DF); however, it was limited to the older population (49 years and older). This study aimed to investigate the possible models of the fractal dimension changes from young to old subjects (10-73 years). A total of 215 right-eye retinal samples, including those of 119 (55%) women and 96 (45%) men, were selected. The retinal vessels were segmented using computer-assisted software, and non-vessel fragments were deleted. The fractal dimension was measured based on the log-log plot of the number of grids versus the size. The retinal vascular DF was analyzed to determine changes with increasing age. Finally, the data were fitted to three polynomial models. All three models are statistically significant (Linear: R2=0.1270, 213 d.f., p<0.001, Quadratic: R2=0.1536, 212 d.f., p<0.001, Cubic: R2=0.1529, 211 d.f., p<0.001). The quadratic regression is significantly better than the linear regression (p<0.001); however, the increase in R2 from the quadratic model to the cubic model is not significant (p=0.97). These results suggest that the decreasing trend of the fractal dimension associated with aging is better explained by the quadratic model than by the linear and cubic models in a sample with a broader age spectrum.

Original languageEnglish
Pages (from-to)355-358
Number of pages4
JournalExperimental Eye Research
Volume116
DOIs
Publication statusPublished - Nov 2013

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Fractals
Retinal Vessels
Linear Models
Statistical Models
Software
Population

Keywords

  • Fractal dimension
  • Retinal vasculature

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

Cite this

Che Azemin, M. Z., Ab Hamid, F., Aminuddin, A., Wang, J. J., Kawasaki, R., & Kumar, D. K. (2013). Age-related rarefaction in retinal vasculature is not linear. Experimental Eye Research, 116, 355-358. https://doi.org/10.1016/j.exer.2013.10.010

Age-related rarefaction in retinal vasculature is not linear. / Che Azemin, M. Z.; Ab Hamid, F.; Aminuddin, Amilia; Wang, J. J.; Kawasaki, R.; Kumar, D. K.

In: Experimental Eye Research, Vol. 116, 11.2013, p. 355-358.

Research output: Contribution to journalArticle

Che Azemin, MZ, Ab Hamid, F, Aminuddin, A, Wang, JJ, Kawasaki, R & Kumar, DK 2013, 'Age-related rarefaction in retinal vasculature is not linear', Experimental Eye Research, vol. 116, pp. 355-358. https://doi.org/10.1016/j.exer.2013.10.010
Che Azemin, M. Z. ; Ab Hamid, F. ; Aminuddin, Amilia ; Wang, J. J. ; Kawasaki, R. ; Kumar, D. K. / Age-related rarefaction in retinal vasculature is not linear. In: Experimental Eye Research. 2013 ; Vol. 116. pp. 355-358.
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