Age-related changes in the metabolic profiles of rat hippocampus, medial prefrontal cortex and striatum

Lina Wati Durani, Hamizah Shahirah Hamezah, Nor Faeizah Ibrahim, Daijiro Yanagisawa, Suzana Makpol, Mohd Hanafi Ahmad Damanhuri, Ikuo Tooyama

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

We have recently shown that age-dependent regional brain atrophy and lateral ventricle expansion may be linked with impaired cognitive and locomotor functions. However, metabolic profile transformation in different brain regions during aging is unknown. This study examined metabolic changes in the hippocampus, medial prefrontal cortex (mPFC) and striatum of middle- and late-aged Sprague-Dawley rats using ultrahigh performance liquid chromatography coupled with high-resolution accurate mass-orbitrap tandem mass spectrometry. Thirty-eight potential metabolites were altered in hippocampus, 29 in mPFC, and 14 in striatum. These alterations indicated that regional metabolic mechanisms in lated-aged rats are related to multiple pathways including glutathione, sphingolipid, tyrosine, and purine metabolism. Thus, our findings might be useful for understanding the complexity of metabolic mechanisms in aging and provide insight for aging and health span.

Original languageEnglish
Pages (from-to)1356-1363
Number of pages8
JournalBiochemical and Biophysical Research Communications
Volume493
Issue number3
DOIs
Publication statusPublished - 25 Nov 2017

Fingerprint

Metabolome
Prefrontal Cortex
Rats
Hippocampus
Aging of materials
Sphingolipids
Lateral Ventricles
Brain
Tandem Mass Spectrometry
Liquid Chromatography
Cognition
Atrophy
Glutathione
Sprague Dawley Rats
Tyrosine
Liquid chromatography
Metabolites
Metabolism
Mass spectrometry
Health

Keywords

  • Aging
  • Hippocampus
  • Medial prefrontal cortex
  • Metabolomics
  • Striatum

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

Age-related changes in the metabolic profiles of rat hippocampus, medial prefrontal cortex and striatum. / Durani, Lina Wati; Hamezah, Hamizah Shahirah; Ibrahim, Nor Faeizah; Yanagisawa, Daijiro; Makpol, Suzana; Ahmad Damanhuri, Mohd Hanafi; Tooyama, Ikuo.

In: Biochemical and Biophysical Research Communications, Vol. 493, No. 3, 25.11.2017, p. 1356-1363.

Research output: Contribution to journalArticle

Durani, Lina Wati ; Hamezah, Hamizah Shahirah ; Ibrahim, Nor Faeizah ; Yanagisawa, Daijiro ; Makpol, Suzana ; Ahmad Damanhuri, Mohd Hanafi ; Tooyama, Ikuo. / Age-related changes in the metabolic profiles of rat hippocampus, medial prefrontal cortex and striatum. In: Biochemical and Biophysical Research Communications. 2017 ; Vol. 493, No. 3. pp. 1356-1363.
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