Adventitial ablation technique that permits the assessment of adventitial-dependent contribution to microvascular contractile function

Satirah Zainalabidin, Roger M. Wadsworth, Paul Coats

Research output: Contribution to journalArticle

Abstract

Resistance arteries have been implicated as a major contributing factor in the sequela of disease conditions such as hypertension and diabetes and, as such, are a major focus of cardiovascular research. The paracrine influence of the intimal endothelial layer of resistance arteries is well established. Considering the growing body of evidence substantiating a functionally relevant vascular adventitia, in this study we have established a technique that permits determination of the functional influence of the adventitial layer on resistance artery tone. Isolating adventitial-dependent function, analogous to isolating endothelial function, has potentially significant implications for studying the as yet unexplored role of the microvascular adventitial layer in modulating acute vascular contractile function.

Original languageEnglish
Pages (from-to)71-77
Number of pages7
JournalAnalytical Biochemistry
Volume499
DOIs
Publication statusPublished - 15 Apr 2016
Externally publishedYes

Fingerprint

Ablation Techniques
Adventitia
Ablation
Arteries
Blood Vessels
Tunica Intima
Medical problems
Hypertension
Research

Keywords

  • Adventitia
  • Microcirculation
  • Pressure autoregulation
  • Vasoconstriction
  • Vasorelaxation

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology
  • Cell Biology

Cite this

Adventitial ablation technique that permits the assessment of adventitial-dependent contribution to microvascular contractile function. / Zainalabidin, Satirah; Wadsworth, Roger M.; Coats, Paul.

In: Analytical Biochemistry, Vol. 499, 15.04.2016, p. 71-77.

Research output: Contribution to journalArticle

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