Adiponectin SNP45TG is associated with gestational diabetes mellitus

Low Chen Fei, Eusni Rahayu Mohd Tohit, Pei Pei Chong, Faridah Idris

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Introduction: Diabetes and pregnancy can be associated in two ways: pregnancy that occurs in women who are already diabetic (diabetes of pre-gestational origin); and diabetes that occur in women who are already pregnant [gestational diabetes mellitus (GDM) (O'sullivan 1961)]. Patients with previous GDM history have higher risk of developing diabetes outside of pregnancy. Accumulating literature had suggested that adiponectin plays a role in the pathophysiology of this metabolic syndrome, and several of the common single nucleotide polymorphisms (SNP) in adiponectin gene have been identified in type 2 diabetes. Thus, one of the commonly found SNP was studied to determine its association with GDM. Objective: To identify the association of SNP45TG with GDM. Methods: This is a cross-sectional study involving pregnant mothers of 1c percentage were also examined. Results: Among the 79 antenatal patients recruited, 53 patients were normal and 26 were diagnosed with GDM. Among the 53 normal patients, 18 carry TG/GG genotype. Meanwhile, among the 26 patients that were diagnosed with GDM 15 carry TG/GG genotype. Significant association was found between SNP45TG with GDM ( χ2 = 4.038; P <0.05). In addition, normal patients with TT genotype have significantly higher plasma adiponectin level compared to other groups. Conclusion: We concluded that SNP45TG in adiponectin gene is associated with the occurrence of GDM.

Original languageEnglish
Pages (from-to)1255-1260
Number of pages6
JournalArchives of Gynecology and Obstetrics
Volume283
Issue number6
DOIs
Publication statusPublished - Jun 2011
Externally publishedYes

Fingerprint

Gestational Diabetes
Adiponectin
Genotype
Pregnancy
Single Nucleotide Polymorphism
Type 2 Diabetes Mellitus
Genes
Cross-Sectional Studies
Mothers

Keywords

  • Adiponectin
  • Gestational diabetes mellitus
  • Single nucleotide polymorphism
  • SNP45

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

Cite this

Adiponectin SNP45TG is associated with gestational diabetes mellitus. / Chen Fei, Low; Mohd Tohit, Eusni Rahayu; Chong, Pei Pei; Idris, Faridah.

In: Archives of Gynecology and Obstetrics, Vol. 283, No. 6, 06.2011, p. 1255-1260.

Research output: Contribution to journalArticle

Chen Fei, Low ; Mohd Tohit, Eusni Rahayu ; Chong, Pei Pei ; Idris, Faridah. / Adiponectin SNP45TG is associated with gestational diabetes mellitus. In: Archives of Gynecology and Obstetrics. 2011 ; Vol. 283, No. 6. pp. 1255-1260.
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