Acute toxicity study of Cosmos caudatus on biochemical parameters in male rats

Norazlina Mohamed, S. Z. Ehsan, K. Noor 'Adilah, C. P. Lee, E. Farhana, P. Derick, Ima Nirwana Soelaiman, Ahmad Nazrun Shuid, Norliza Muhammad

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Cosmos caudatus or 'ulam raja' is a local plant with antioxidant properties and has the potential to treat free radicals-associated diseases. However, its toxic effects need to be elucidated. Acute toxicity study was carried out in male rats. Rats aged 3 months, weighing 150-200 g were divided into 4 groups, i.e. rats being fed on distilled water (control), Cosmos caudatus extract dose 50 mg/kg (CC50), Cosmos caudatus 500 mg/kg (CC500) and Cosmos caudatus 2000 mg/kg (CC2000), respectively. A single treatment was given to the respective groups and the animals were sacrificed after 7 days. Biochemical parameters before and after treatment were measured. Liver enzymes, i.e. alkaline phosphatase (ALP) and alanine transaminase (ALT), were found to be increased post treatment in CC500 and CC2000 groups. Creatinine levels were lower in CC500 and CC2000 groups post treatment compared with control group while albumin levels were lower in CC2000 group than all the other groups. In conclusion, Cosmos caudatus may cause acute hepatotoxicity at high doses.

Original languageEnglish
Pages (from-to)1247-1251
Number of pages5
JournalSains Malaysiana
Volume42
Issue number9
Publication statusPublished - Sep 2013

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Skates (Fish)
Poisons
Alanine Transaminase
Free Radicals
Alkaline Phosphatase
Albumins
Creatinine
Antioxidants
Control Groups
Water
Liver
Enzymes

Keywords

  • Acute toxicity
  • Biochemical parameters
  • Cosmos caudatus

ASJC Scopus subject areas

  • General

Cite this

Mohamed, N., Ehsan, S. Z., Noor 'Adilah, K., Lee, C. P., Farhana, E., Derick, P., ... Muhammad, N. (2013). Acute toxicity study of Cosmos caudatus on biochemical parameters in male rats. Sains Malaysiana, 42(9), 1247-1251.

Acute toxicity study of Cosmos caudatus on biochemical parameters in male rats. / Mohamed, Norazlina; Ehsan, S. Z.; Noor 'Adilah, K.; Lee, C. P.; Farhana, E.; Derick, P.; Soelaiman, Ima Nirwana; Shuid, Ahmad Nazrun; Muhammad, Norliza.

In: Sains Malaysiana, Vol. 42, No. 9, 09.2013, p. 1247-1251.

Research output: Contribution to journalArticle

Mohamed, N, Ehsan, SZ, Noor 'Adilah, K, Lee, CP, Farhana, E, Derick, P, Soelaiman, IN, Shuid, AN & Muhammad, N 2013, 'Acute toxicity study of Cosmos caudatus on biochemical parameters in male rats', Sains Malaysiana, vol. 42, no. 9, pp. 1247-1251.
Mohamed N, Ehsan SZ, Noor 'Adilah K, Lee CP, Farhana E, Derick P et al. Acute toxicity study of Cosmos caudatus on biochemical parameters in male rats. Sains Malaysiana. 2013 Sep;42(9):1247-1251.
Mohamed, Norazlina ; Ehsan, S. Z. ; Noor 'Adilah, K. ; Lee, C. P. ; Farhana, E. ; Derick, P. ; Soelaiman, Ima Nirwana ; Shuid, Ahmad Nazrun ; Muhammad, Norliza. / Acute toxicity study of Cosmos caudatus on biochemical parameters in male rats. In: Sains Malaysiana. 2013 ; Vol. 42, No. 9. pp. 1247-1251.
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