Acute haemolysis secondary to low dose of intravenous immunoglobulins

Rozita Mohd, A. R. Mohamad Fadli, Rizna Abdul Cader

Research output: Contribution to journalArticle

Abstract

Intravenous immunoglobulin is beneficial in treating lupus nephritis at various stages of treatment. It is generally well tolerated with mild and transient side effects. We report a case of a young man with recalcitrant lupus nephritis who was treated with three courses of intravenous immunoglobulin of 100 grams, 60 grams and 15 grams respectively within 5 months. During the last course, he developed acute haemolysis on day 3 of treatment; haemoglobin dropped by 3 grams, elevated lactate dehydrogenase, reticulocytosis and haemoglobinuria. Full blood picture revealed typical haemolysis findings. Immediate improvement was observed after stopping the immunoglobulin and with transfusion of 2 pints of packed cell.

Original languageEnglish
Pages (from-to)33-35
Number of pages3
JournalBrunei International Medical Journal
Volume13
Issue number1
Publication statusPublished - 2017

Fingerprint

Lupus Nephritis
Intravenous Immunoglobulins
Hemolysis
Reticulocytosis
Hemoglobinuria
L-Lactate Dehydrogenase
Immunoglobulins
Hemoglobins
Therapeutics

Keywords

  • Immune thrombocytopenic purpura
  • Immunoglobulin
  • Lupus nephritis
  • Systemic lupus erythematosus

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Acute haemolysis secondary to low dose of intravenous immunoglobulins. / Mohd, Rozita; Mohamad Fadli, A. R.; Abdul Cader, Rizna.

In: Brunei International Medical Journal, Vol. 13, No. 1, 2017, p. 33-35.

Research output: Contribution to journalArticle

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