Acute effect of low and high glycemic index meals on post-prandial glycemia and insulin responses in patients with type 2 diabetes mellitus

M. Y. Barakatun Nisak, Ruzita Abd. Talib, Norimah A. Karim, Nor Azmi Kamaruddin, A. Fatimah

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Abstract

Introduction: Post-prandial hyperglycemia is an important independent risk factor in the development of cardiovascular disease in diabetes. This randomised cross-over study was conducted to compare the post-prandial glycémie and insulin responses to both high and low glycémie index (GI) meals in patients with type 2 diabetes (T2DM). Methods: A total of 41 patients with established T2DM (16 males, 25 females, Age= 55 ± 10 years and BMI= 27 ± 4 kg/m 2) were randomly given either a High GI or a Low GI meal in a cross-over manner. Both test meals were separated by one week washout periods. The meals contained almost the same amount of energy and macronutrients with the exception of the GI values (High GI=70 vs Low GI= 36). Venous blood was taken through an indwelling catheter periodically at 0, 30, 60, 90, 120, 150 and 180 minutes respectively. The incremental area under the curve (iAUC) was used to calculate the post-prandial glycemia and insulin excursion over the 3-hour period. Results: The low GI meal induced lower glycemic responses at times 30,60,90 and 120 minutes (mean±SE; low GI=8.1±0.4,9. 1±0.4,8.9±0.4 and 8.5±0.4 mmol/1 vs high GI= 9.1±0.4,10.7±0.4,11.0±0.5 and 9.7±0.5 mmol/1) and reduced the insulin levels at time 60, 90, 120 and 150 minutes (mean±SE; low GI= 17.1+1.7, 21.1±2.0, 20.4±1.7, 18.5±1.8 vs high GI= 25.0±2.5, 31.2±2.9,29.8±3.0 and 23.0±2.3 μIU/ml) (p<0.05). The area under the glycemic (mean±SE; low GI= 215.93 ± 15.9 mmol.L/minute vs high GI= 419.52 ± 32.7 mmol.L/minute) and insulin (mean±SE; low GI= 1439.76 ± 226 vs high GI= 2372.76 ± 317μIU.ml/min) curves were lower after the low GI than high GI meal respectively (p<0.05). Conclusion: The low GI meal has the ability to reduce the post-prandial hyperglycemia as well insulin responses in type 2 diabetes patients.

Original languageEnglish
Pages (from-to)11-20
Number of pages10
JournalMalaysian Journal of Medicine and Health Sciences
Volume5
Issue number1
Publication statusPublished - Jan 2009

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Glycemic Index
Type 2 Diabetes Mellitus
Meals
Insulin
Hyperglycemia
Indwelling Catheters
Cross-Over Studies
Area Under Curve
Cardiovascular Diseases

Keywords

  • Glycemic index
  • Insulin concentration
  • Post-prandial hyperglycemia
  • Type 2 diabetes

ASJC Scopus subject areas

  • Medicine(all)

Cite this

@article{dce56b5ca07f419f84ae45f7f8df3114,
title = "Acute effect of low and high glycemic index meals on post-prandial glycemia and insulin responses in patients with type 2 diabetes mellitus",
abstract = "Introduction: Post-prandial hyperglycemia is an important independent risk factor in the development of cardiovascular disease in diabetes. This randomised cross-over study was conducted to compare the post-prandial glyc{\'e}mie and insulin responses to both high and low glyc{\'e}mie index (GI) meals in patients with type 2 diabetes (T2DM). Methods: A total of 41 patients with established T2DM (16 males, 25 females, Age= 55 ± 10 years and BMI= 27 ± 4 kg/m 2) were randomly given either a High GI or a Low GI meal in a cross-over manner. Both test meals were separated by one week washout periods. The meals contained almost the same amount of energy and macronutrients with the exception of the GI values (High GI=70 vs Low GI= 36). Venous blood was taken through an indwelling catheter periodically at 0, 30, 60, 90, 120, 150 and 180 minutes respectively. The incremental area under the curve (iAUC) was used to calculate the post-prandial glycemia and insulin excursion over the 3-hour period. Results: The low GI meal induced lower glycemic responses at times 30,60,90 and 120 minutes (mean±SE; low GI=8.1±0.4,9. 1±0.4,8.9±0.4 and 8.5±0.4 mmol/1 vs high GI= 9.1±0.4,10.7±0.4,11.0±0.5 and 9.7±0.5 mmol/1) and reduced the insulin levels at time 60, 90, 120 and 150 minutes (mean±SE; low GI= 17.1+1.7, 21.1±2.0, 20.4±1.7, 18.5±1.8 vs high GI= 25.0±2.5, 31.2±2.9,29.8±3.0 and 23.0±2.3 μIU/ml) (p<0.05). The area under the glycemic (mean±SE; low GI= 215.93 ± 15.9 mmol.L/minute vs high GI= 419.52 ± 32.7 mmol.L/minute) and insulin (mean±SE; low GI= 1439.76 ± 226 vs high GI= 2372.76 ± 317μIU.ml/min) curves were lower after the low GI than high GI meal respectively (p<0.05). Conclusion: The low GI meal has the ability to reduce the post-prandial hyperglycemia as well insulin responses in type 2 diabetes patients.",
keywords = "Glycemic index, Insulin concentration, Post-prandial hyperglycemia, Type 2 diabetes",
author = "{Barakatun Nisak}, {M. Y.} and {Abd. Talib}, Ruzita and {A. Karim}, Norimah and Kamaruddin, {Nor Azmi} and A. Fatimah",
year = "2009",
month = "1",
language = "English",
volume = "5",
pages = "11--20",
journal = "Malaysian Journal of Medicine and Health Sciences",
issn = "1675-8544",
publisher = "Faculty of Medicine and Health Sciences, University Putra Malaysia",
number = "1",

}

TY - JOUR

T1 - Acute effect of low and high glycemic index meals on post-prandial glycemia and insulin responses in patients with type 2 diabetes mellitus

AU - Barakatun Nisak, M. Y.

AU - Abd. Talib, Ruzita

AU - A. Karim, Norimah

AU - Kamaruddin, Nor Azmi

AU - Fatimah, A.

PY - 2009/1

Y1 - 2009/1

N2 - Introduction: Post-prandial hyperglycemia is an important independent risk factor in the development of cardiovascular disease in diabetes. This randomised cross-over study was conducted to compare the post-prandial glycémie and insulin responses to both high and low glycémie index (GI) meals in patients with type 2 diabetes (T2DM). Methods: A total of 41 patients with established T2DM (16 males, 25 females, Age= 55 ± 10 years and BMI= 27 ± 4 kg/m 2) were randomly given either a High GI or a Low GI meal in a cross-over manner. Both test meals were separated by one week washout periods. The meals contained almost the same amount of energy and macronutrients with the exception of the GI values (High GI=70 vs Low GI= 36). Venous blood was taken through an indwelling catheter periodically at 0, 30, 60, 90, 120, 150 and 180 minutes respectively. The incremental area under the curve (iAUC) was used to calculate the post-prandial glycemia and insulin excursion over the 3-hour period. Results: The low GI meal induced lower glycemic responses at times 30,60,90 and 120 minutes (mean±SE; low GI=8.1±0.4,9. 1±0.4,8.9±0.4 and 8.5±0.4 mmol/1 vs high GI= 9.1±0.4,10.7±0.4,11.0±0.5 and 9.7±0.5 mmol/1) and reduced the insulin levels at time 60, 90, 120 and 150 minutes (mean±SE; low GI= 17.1+1.7, 21.1±2.0, 20.4±1.7, 18.5±1.8 vs high GI= 25.0±2.5, 31.2±2.9,29.8±3.0 and 23.0±2.3 μIU/ml) (p<0.05). The area under the glycemic (mean±SE; low GI= 215.93 ± 15.9 mmol.L/minute vs high GI= 419.52 ± 32.7 mmol.L/minute) and insulin (mean±SE; low GI= 1439.76 ± 226 vs high GI= 2372.76 ± 317μIU.ml/min) curves were lower after the low GI than high GI meal respectively (p<0.05). Conclusion: The low GI meal has the ability to reduce the post-prandial hyperglycemia as well insulin responses in type 2 diabetes patients.

AB - Introduction: Post-prandial hyperglycemia is an important independent risk factor in the development of cardiovascular disease in diabetes. This randomised cross-over study was conducted to compare the post-prandial glycémie and insulin responses to both high and low glycémie index (GI) meals in patients with type 2 diabetes (T2DM). Methods: A total of 41 patients with established T2DM (16 males, 25 females, Age= 55 ± 10 years and BMI= 27 ± 4 kg/m 2) were randomly given either a High GI or a Low GI meal in a cross-over manner. Both test meals were separated by one week washout periods. The meals contained almost the same amount of energy and macronutrients with the exception of the GI values (High GI=70 vs Low GI= 36). Venous blood was taken through an indwelling catheter periodically at 0, 30, 60, 90, 120, 150 and 180 minutes respectively. The incremental area under the curve (iAUC) was used to calculate the post-prandial glycemia and insulin excursion over the 3-hour period. Results: The low GI meal induced lower glycemic responses at times 30,60,90 and 120 minutes (mean±SE; low GI=8.1±0.4,9. 1±0.4,8.9±0.4 and 8.5±0.4 mmol/1 vs high GI= 9.1±0.4,10.7±0.4,11.0±0.5 and 9.7±0.5 mmol/1) and reduced the insulin levels at time 60, 90, 120 and 150 minutes (mean±SE; low GI= 17.1+1.7, 21.1±2.0, 20.4±1.7, 18.5±1.8 vs high GI= 25.0±2.5, 31.2±2.9,29.8±3.0 and 23.0±2.3 μIU/ml) (p<0.05). The area under the glycemic (mean±SE; low GI= 215.93 ± 15.9 mmol.L/minute vs high GI= 419.52 ± 32.7 mmol.L/minute) and insulin (mean±SE; low GI= 1439.76 ± 226 vs high GI= 2372.76 ± 317μIU.ml/min) curves were lower after the low GI than high GI meal respectively (p<0.05). Conclusion: The low GI meal has the ability to reduce the post-prandial hyperglycemia as well insulin responses in type 2 diabetes patients.

KW - Glycemic index

KW - Insulin concentration

KW - Post-prandial hyperglycemia

KW - Type 2 diabetes

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M3 - Article

AN - SCOPUS:65449116461

VL - 5

SP - 11

EP - 20

JO - Malaysian Journal of Medicine and Health Sciences

JF - Malaysian Journal of Medicine and Health Sciences

SN - 1675-8544

IS - 1

ER -