Acute and subacute toxicity of Persicaria minor in wistar rats

Norliza Muhammad, Elliza Mansor, Yap Chuan Sang, Nor Syahira Shariffudin, Amri Dahdi, Ahmad Fadhil Alias, Norazlina Mohamed, Ahmad Nazrun Shuid, Abd. Salam Babji, Ima Nirwana Soelaiman

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Persicaria minor a widely used herb in South-east Asia, was reported to have high antioxidant contents and therefore can be potentially used to reverse the effects of lipid peroxidation caused by free radicals. In this study, the toxicity profile of this herb was evaluated based on haematological and biochemical analyses. In acute toxicity study, male Wistar rats were given a single dose of either 300, 1000 or 2000 mg kg-1 b.wt. of aqueous extract of Persicaria minor leaves via oral gavage. Rats were observed for mortality within 24 h. In subacute toxicity study, the rats were treated with the three different doses of the extract daily for fourteen days. At the end of the study period, blood was taken intraorbitally for haematology and biochemistry. Results showed that there were no signs of toxicity, behavioural changes or death observed in both studies. However, feeding of extract at the dose of 2000 mg kg-1 b.wt. for 14 days significantly reduced the haemoglobin, calcium and sodium while increasing the potassium levels. In conclusion, the extract from the leaves of Persicaria minor administered orally did not cause any acute or subacute toxicity to male rats, with the exception of the extremely large dose whereby it may lead to electrolyte imbalance, anaemia and hypocalcaerma.

Original languageEnglish
Pages (from-to)47-55
Number of pages9
JournalAsian Journal of Animal Sciences
Volume7
Issue number2
DOIs
Publication statusPublished - 2013

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subacute toxicity
acute toxicity
toxicity testing
rats
extracts
dosage
herbs
hematology
South East Asia
biochemistry
anemia
electrolytes
leaves
mouth
hemoglobin
lipid peroxidation
potassium
sodium
death
toxicity

Keywords

  • Antioxidant
  • Biochemical and haematological analyses
  • Persicaria minor
  • Toxicity

ASJC Scopus subject areas

  • Animal Science and Zoology

Cite this

Acute and subacute toxicity of Persicaria minor in wistar rats. / Muhammad, Norliza; Mansor, Elliza; Sang, Yap Chuan; Shariffudin, Nor Syahira; Dahdi, Amri; Alias, Ahmad Fadhil; Mohamed, Norazlina; Shuid, Ahmad Nazrun; Babji, Abd. Salam; Soelaiman, Ima Nirwana.

In: Asian Journal of Animal Sciences, Vol. 7, No. 2, 2013, p. 47-55.

Research output: Contribution to journalArticle

Muhammad, Norliza ; Mansor, Elliza ; Sang, Yap Chuan ; Shariffudin, Nor Syahira ; Dahdi, Amri ; Alias, Ahmad Fadhil ; Mohamed, Norazlina ; Shuid, Ahmad Nazrun ; Babji, Abd. Salam ; Soelaiman, Ima Nirwana. / Acute and subacute toxicity of Persicaria minor in wistar rats. In: Asian Journal of Animal Sciences. 2013 ; Vol. 7, No. 2. pp. 47-55.
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