Acuminatol and other antioxidative resveratrol oligomers from the stem bark of Shorea acuminata

Norhayati Muhammad, Laily B. Din, Idin Sahidin, Siti Farah Hashim, Nazlina Ibrahim, Zuriati Zakaria, Wan Yaacob Wan Ahmad

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

A new resveratrol dimer, acuminatol (1), was isolated along with five known compounds from the acetone extract of the stem bark of Shorea acuminata. Their structures and stereochemistry were determined by spectroscopic methods, which included the extensive use of 2D NMR techniques. All isolated compounds were evaluated for their antioxidant activity using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity (RSA) and the β-carotene-linoleic acid (BCLA) assays, and compared with those of the standards of ascorbic acid (AscA) and butylated hydroxytoluene (BHT). All compounds tested exhibited good to moderate antioxidant activity in the DPPH assay (IC 50s 0.84 to 10.06 mM) and displayed strong inhibition of β-carotene oxidation (IC 50s 0.10 to 0.22 mM). The isolated compounds were evaluated on the Vero cell line and were found to be non-cytotoxic with LC 50 values between 161 to 830 μM.

Original languageEnglish
Pages (from-to)9043-9055
Number of pages13
JournalMolecules
Volume17
Issue number8
DOIs
Publication statusPublished - Aug 2012

Fingerprint

Dipterocarpaceae
Carotenoids
stems
oligomers
Oligomers
carotene
Assays
Antioxidants
antioxidants
Butylated Hydroxytoluene
Stereochemistry
Vero Cells
Scavenging
Linoleic Acid
Acetone
Dimers
Ascorbic Acid
ascorbic acid
scavenging
Cells

Keywords

  • Acuminatol
  • Antioxidant activity
  • Cytotoxicity
  • Dipterocarpaceae
  • Resveratrol oligomer
  • Shorea acuminata

ASJC Scopus subject areas

  • Organic Chemistry
  • Medicine(all)

Cite this

Muhammad, N., Din, L. B., Sahidin, I., Hashim, S. F., Ibrahim, N., Zakaria, Z., & Wan Ahmad, W. Y. (2012). Acuminatol and other antioxidative resveratrol oligomers from the stem bark of Shorea acuminata. Molecules, 17(8), 9043-9055. https://doi.org/10.3390/molecules17089043

Acuminatol and other antioxidative resveratrol oligomers from the stem bark of Shorea acuminata. / Muhammad, Norhayati; Din, Laily B.; Sahidin, Idin; Hashim, Siti Farah; Ibrahim, Nazlina; Zakaria, Zuriati; Wan Ahmad, Wan Yaacob.

In: Molecules, Vol. 17, No. 8, 08.2012, p. 9043-9055.

Research output: Contribution to journalArticle

Muhammad, N, Din, LB, Sahidin, I, Hashim, SF, Ibrahim, N, Zakaria, Z & Wan Ahmad, WY 2012, 'Acuminatol and other antioxidative resveratrol oligomers from the stem bark of Shorea acuminata', Molecules, vol. 17, no. 8, pp. 9043-9055. https://doi.org/10.3390/molecules17089043
Muhammad, Norhayati ; Din, Laily B. ; Sahidin, Idin ; Hashim, Siti Farah ; Ibrahim, Nazlina ; Zakaria, Zuriati ; Wan Ahmad, Wan Yaacob. / Acuminatol and other antioxidative resveratrol oligomers from the stem bark of Shorea acuminata. In: Molecules. 2012 ; Vol. 17, No. 8. pp. 9043-9055.
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