Activity of extracts and isolated naphthoquinones from Kigelia pinnata against Plasmodium falciparum

C. R. Weiss, S. V K Moideen, S. L. Croft, P. J. Houghton

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

Four naphthoquinoids from Kigelia pinnata rootbark were assessed in vitro against chloroquine-sensitive (T9-96) and -resistant (K1) Plasmodium falciparum strains and for cytotoxicity using KB cells. 2-(1-Hydroxyethyl)naphtho[2,3-b]furan-4,9-dione possessed good activity against both strains [IC50 values 627 nM (K1), 718 nM (T9-96)]. Isopinnatal, kigelinol, and isokigelinol exhibited lower activity against both strains.

Original languageEnglish
Pages (from-to)1306-1309
Number of pages4
JournalJournal of Natural Products
Volume63
Issue number9
DOIs
Publication statusPublished - 2000
Externally publishedYes

Fingerprint

Naphthoquinones
KB Cells
naphthoquinones
Chloroquine
Plasmodium falciparum
Inhibitory Concentration 50
extracts
chloroquine
furans
Cytotoxicity
inhibitory concentration 50
cytotoxicity
In Vitro Techniques
naphtho(2,3-b)furan-4,9-dione
isopinnatal
Kigelia africana
cells

ASJC Scopus subject areas

  • Plant Science
  • Chemistry (miscellaneous)
  • Drug Discovery
  • Organic Chemistry
  • Pharmacology

Cite this

Activity of extracts and isolated naphthoquinones from Kigelia pinnata against Plasmodium falciparum. / Weiss, C. R.; Moideen, S. V K; Croft, S. L.; Houghton, P. J.

In: Journal of Natural Products, Vol. 63, No. 9, 2000, p. 1306-1309.

Research output: Contribution to journalArticle

Weiss, C. R. ; Moideen, S. V K ; Croft, S. L. ; Houghton, P. J. / Activity of extracts and isolated naphthoquinones from Kigelia pinnata against Plasmodium falciparum. In: Journal of Natural Products. 2000 ; Vol. 63, No. 9. pp. 1306-1309.
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