Activities of γ-glutamyl transpeptidase and erythrocyte glutathione dependent enzymes in nasopharyngeal carcinoma patients and normal controls

W. Z W Ngah, N. A. Shamaan, M. H. Said, M. T. Azhar

    Research output: Contribution to journalArticle

    1 Citation (Scopus)

    Abstract

    Plasma γ-glutamyltranspeptidase (γ-GT), glutathione peroxidase (GPx) and glutathione reductase (GR) activities were determined in normal and nasopharyngeal carcinoma (NPC) patients. No difference in enzyme activities was observed in the three major races of the Malaysian population, i.e. Malay, Chinese and Indian patients. However, plasma γ-GT, erythrocyte glutathione S-transferase (GST) and GPx activities were significantly increased in all NPC patients, while GR activity remained unchanged. Patients with elevated plasma γ-GT activities also had increased GST and GPx activities. Plasma γ-GT and GPx activities were then found to be affected by treatment. Patients with plasma γ-GT activity greater than 70 IU/1 had very poor prognoses but patients with decreased γ-GT activities were found to be in remission.

    Original languageEnglish
    Pages (from-to)304-307
    Number of pages4
    JournalEuropean Archives of Oto-Rhino-Laryngology
    Volume250
    Issue number5
    DOIs
    Publication statusPublished - Sep 1993

    Fingerprint

    gamma-Glutamyltransferase
    Glutathione
    Erythrocytes
    Glutathione Peroxidase
    Enzymes
    Glutathione Reductase
    Glutathione Transferase
    Nasopharyngeal carcinoma
    Population

    Keywords

    • Glutathione-dependent enzymes
    • Nasopharyngeal carcinoma
    • Plasma γ-glutamyl transpeptidase
    • Prognosis

    ASJC Scopus subject areas

    • Otorhinolaryngology

    Cite this

    Activities of γ-glutamyl transpeptidase and erythrocyte glutathione dependent enzymes in nasopharyngeal carcinoma patients and normal controls. / Ngah, W. Z W; Shamaan, N. A.; Said, M. H.; Azhar, M. T.

    In: European Archives of Oto-Rhino-Laryngology, Vol. 250, No. 5, 09.1993, p. 304-307.

    Research output: Contribution to journalArticle

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    AB - Plasma γ-glutamyltranspeptidase (γ-GT), glutathione peroxidase (GPx) and glutathione reductase (GR) activities were determined in normal and nasopharyngeal carcinoma (NPC) patients. No difference in enzyme activities was observed in the three major races of the Malaysian population, i.e. Malay, Chinese and Indian patients. However, plasma γ-GT, erythrocyte glutathione S-transferase (GST) and GPx activities were significantly increased in all NPC patients, while GR activity remained unchanged. Patients with elevated plasma γ-GT activities also had increased GST and GPx activities. Plasma γ-GT and GPx activities were then found to be affected by treatment. Patients with plasma γ-GT activity greater than 70 IU/1 had very poor prognoses but patients with decreased γ-GT activities were found to be in remission.

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