Pemerolehan, analisis dan interpretasi data fMRI: Kehubungan efektif dalam korteks auditori primer manusia

Translated title of the contribution: Acquisition, analyses and interpretation of fmri data: A study on the effective connectivity in human primary auditory cortices

Ahmad Nazlim Yusoff, Mazlyfarina Mohamad, Khairiah Abdul Hamid, Aini Ismafairus Abd Hamid, Siti Zamratol Mai Sarah Mukari

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

A study on the effective connectivity characteristics in auditory cortices was conducted on five healthy Malay male subjects with the age of 20 to 40 years old using functional magnetic resonance imaging (fMRI), statistical parametric mapping (SPM5) and dynamic causal modelling (DCM). A silent imaging paradigm was used to reduce the scanner sound artefacts on functional images. The subjects were instructed to pay attention to the white noise stimulus binaurally given at intensity level of 70 dB higher than the hearing level for normal people. Functional specialisation was studied using Matlab-based SPM5 software by means of fixed effects (FFX), random effects (RFX) and conjunction analyses. Individual analyses on all subjects indicate asymmetrical bilateral activation between the left and right auditory cortices in Brodmann areas (BA)22, 41 and 42 involving the primary and secondary auditory cortices. The three auditory areas in the right and left auditory cortices are selected for the determination of the effective connectivity by constructing 9 network models. The effective connectivity is determined on four out of five subjects with the exception of one subject who has the BA22 coordinates located too far from BA22 coordinates obtained from group analysis. DCM results showed the existence of effective connectivity between the three selected auditory areas in both auditory cortices. In the right auditory cortex, BA42 is identified as input centre with unidirectional parallel effective connectivities of BA42 → BA4I and BA42 → BA22. However, for the left auditory cortex, the input is BA4I with unidirectional parallel effective connectivities of BA4I → BA42 and BA4I→BA22. The connectivity between the activated auditory areas suggests the existence of signal pathway in the auditory cortices even when the subject is listening to noise.

Original languageUndefined/Unknown
Pages (from-to)665-678
Number of pages14
JournalSains Malaysiana
Volume40
Issue number6
Publication statusPublished - Jun 2011

Fingerprint

Auditory Cortex
Artifacts
Hearing
Noise
Signal Transduction
Software
Magnetic Resonance Imaging

Keywords

  • Brodmann area
  • Dynamic causal modeling
  • Functional magnetic resonance imaging
  • Statistical parametric mapping

ASJC Scopus subject areas

  • General

Cite this

Pemerolehan, analisis dan interpretasi data fMRI : Kehubungan efektif dalam korteks auditori primer manusia. / Yusoff, Ahmad Nazlim; Mohamad, Mazlyfarina; Abdul Hamid, Khairiah; Abd Hamid, Aini Ismafairus; Mukari, Siti Zamratol Mai Sarah.

In: Sains Malaysiana, Vol. 40, No. 6, 06.2011, p. 665-678.

Research output: Contribution to journalArticle

Yusoff, Ahmad Nazlim ; Mohamad, Mazlyfarina ; Abdul Hamid, Khairiah ; Abd Hamid, Aini Ismafairus ; Mukari, Siti Zamratol Mai Sarah. / Pemerolehan, analisis dan interpretasi data fMRI : Kehubungan efektif dalam korteks auditori primer manusia. In: Sains Malaysiana. 2011 ; Vol. 40, No. 6. pp. 665-678.
@article{1206ca18edd6489bae242fa0c0e311e4,
title = "Pemerolehan, analisis dan interpretasi data fMRI: Kehubungan efektif dalam korteks auditori primer manusia",
abstract = "A study on the effective connectivity characteristics in auditory cortices was conducted on five healthy Malay male subjects with the age of 20 to 40 years old using functional magnetic resonance imaging (fMRI), statistical parametric mapping (SPM5) and dynamic causal modelling (DCM). A silent imaging paradigm was used to reduce the scanner sound artefacts on functional images. The subjects were instructed to pay attention to the white noise stimulus binaurally given at intensity level of 70 dB higher than the hearing level for normal people. Functional specialisation was studied using Matlab-based SPM5 software by means of fixed effects (FFX), random effects (RFX) and conjunction analyses. Individual analyses on all subjects indicate asymmetrical bilateral activation between the left and right auditory cortices in Brodmann areas (BA)22, 41 and 42 involving the primary and secondary auditory cortices. The three auditory areas in the right and left auditory cortices are selected for the determination of the effective connectivity by constructing 9 network models. The effective connectivity is determined on four out of five subjects with the exception of one subject who has the BA22 coordinates located too far from BA22 coordinates obtained from group analysis. DCM results showed the existence of effective connectivity between the three selected auditory areas in both auditory cortices. In the right auditory cortex, BA42 is identified as input centre with unidirectional parallel effective connectivities of BA42 → BA4I and BA42 → BA22. However, for the left auditory cortex, the input is BA4I with unidirectional parallel effective connectivities of BA4I → BA42 and BA4I→BA22. The connectivity between the activated auditory areas suggests the existence of signal pathway in the auditory cortices even when the subject is listening to noise.",
keywords = "Brodmann area, Dynamic causal modeling, Functional magnetic resonance imaging, Statistical parametric mapping",
author = "Yusoff, {Ahmad Nazlim} and Mazlyfarina Mohamad and {Abdul Hamid}, Khairiah and {Abd Hamid}, {Aini Ismafairus} and Mukari, {Siti Zamratol Mai Sarah}",
year = "2011",
month = "6",
language = "Undefined/Unknown",
volume = "40",
pages = "665--678",
journal = "Sains Malaysiana",
issn = "0126-6039",
publisher = "Penerbit Universiti Kebangsaan Malaysia",
number = "6",

}

TY - JOUR

T1 - Pemerolehan, analisis dan interpretasi data fMRI

T2 - Kehubungan efektif dalam korteks auditori primer manusia

AU - Yusoff, Ahmad Nazlim

AU - Mohamad, Mazlyfarina

AU - Abdul Hamid, Khairiah

AU - Abd Hamid, Aini Ismafairus

AU - Mukari, Siti Zamratol Mai Sarah

PY - 2011/6

Y1 - 2011/6

N2 - A study on the effective connectivity characteristics in auditory cortices was conducted on five healthy Malay male subjects with the age of 20 to 40 years old using functional magnetic resonance imaging (fMRI), statistical parametric mapping (SPM5) and dynamic causal modelling (DCM). A silent imaging paradigm was used to reduce the scanner sound artefacts on functional images. The subjects were instructed to pay attention to the white noise stimulus binaurally given at intensity level of 70 dB higher than the hearing level for normal people. Functional specialisation was studied using Matlab-based SPM5 software by means of fixed effects (FFX), random effects (RFX) and conjunction analyses. Individual analyses on all subjects indicate asymmetrical bilateral activation between the left and right auditory cortices in Brodmann areas (BA)22, 41 and 42 involving the primary and secondary auditory cortices. The three auditory areas in the right and left auditory cortices are selected for the determination of the effective connectivity by constructing 9 network models. The effective connectivity is determined on four out of five subjects with the exception of one subject who has the BA22 coordinates located too far from BA22 coordinates obtained from group analysis. DCM results showed the existence of effective connectivity between the three selected auditory areas in both auditory cortices. In the right auditory cortex, BA42 is identified as input centre with unidirectional parallel effective connectivities of BA42 → BA4I and BA42 → BA22. However, for the left auditory cortex, the input is BA4I with unidirectional parallel effective connectivities of BA4I → BA42 and BA4I→BA22. The connectivity between the activated auditory areas suggests the existence of signal pathway in the auditory cortices even when the subject is listening to noise.

AB - A study on the effective connectivity characteristics in auditory cortices was conducted on five healthy Malay male subjects with the age of 20 to 40 years old using functional magnetic resonance imaging (fMRI), statistical parametric mapping (SPM5) and dynamic causal modelling (DCM). A silent imaging paradigm was used to reduce the scanner sound artefacts on functional images. The subjects were instructed to pay attention to the white noise stimulus binaurally given at intensity level of 70 dB higher than the hearing level for normal people. Functional specialisation was studied using Matlab-based SPM5 software by means of fixed effects (FFX), random effects (RFX) and conjunction analyses. Individual analyses on all subjects indicate asymmetrical bilateral activation between the left and right auditory cortices in Brodmann areas (BA)22, 41 and 42 involving the primary and secondary auditory cortices. The three auditory areas in the right and left auditory cortices are selected for the determination of the effective connectivity by constructing 9 network models. The effective connectivity is determined on four out of five subjects with the exception of one subject who has the BA22 coordinates located too far from BA22 coordinates obtained from group analysis. DCM results showed the existence of effective connectivity between the three selected auditory areas in both auditory cortices. In the right auditory cortex, BA42 is identified as input centre with unidirectional parallel effective connectivities of BA42 → BA4I and BA42 → BA22. However, for the left auditory cortex, the input is BA4I with unidirectional parallel effective connectivities of BA4I → BA42 and BA4I→BA22. The connectivity between the activated auditory areas suggests the existence of signal pathway in the auditory cortices even when the subject is listening to noise.

KW - Brodmann area

KW - Dynamic causal modeling

KW - Functional magnetic resonance imaging

KW - Statistical parametric mapping

UR - http://www.scopus.com/inward/record.url?scp=79960137352&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79960137352&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:79960137352

VL - 40

SP - 665

EP - 678

JO - Sains Malaysiana

JF - Sains Malaysiana

SN - 0126-6039

IS - 6

ER -