ABCC2 rs2273697 and rs3740066 polymorphisms and resistance to antiepileptic drugs in Asia Pacific epilepsy cohorts

Hidayati Mohd Sha'Ari, Batoul Sadat Haerian, Larry Baum, Junji Saruwatari, Hui Jan Tan, Mohd Hanip Rafia, Raymond Azman Ali, Patrick Kwan, Takateru Ishitsu, Kazuko Nakagawa, Kheng Seang Lim, Zahurin Mohamed

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Aim: To examine the relevance of ABCC2 polymorphisms to drug responsiveness in epilepsy cohorts from the Asia Pacific region. Materials & methods: The rs2273697 and rs3740066 polymorphisms were genotyped in 2056 Malaysian (55%), Hong Kong (32%) and Japanese (13%) epilepsy patients. Results: Significant allele association of rs2273697 was observed in Chinese females with epilepsy, Malaysian Chinese patients with generalized seizure and Japanese patients with partial seizure for the AA versus GG genotype model and Malaysian Chinese patients with generalized seizure for the GA versus GG and autosomal dominant models. Significant association of the rs3740066 allele was observed in Malaysian females of Malay origin with cryptogenic epilepsy and Chinese patients with partial seizure and for genotypes in Malay patients with cryptogenic epilepsy for the CT versus CC and autosomal dominant genotype models. Significant results were observed for all haplotypes, but following Bonferroni correction, only the GT haplotype in Chinese patients remained significant. Conclusion: This study suggests that the GT haplotype might be a risk factor for resistance to medication in Chinese patients.

Original languageEnglish
Pages (from-to)459-466
Number of pages8
JournalPharmacogenomics
Volume15
Issue number4
DOIs
Publication statusPublished - 2014

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Anticonvulsants
Epilepsy
Seizures
Haplotypes
Genotype
Alleles
Hong Kong
Pharmaceutical Preparations

Keywords

  • drug responsiveness
  • epilepsy
  • polymorphism

ASJC Scopus subject areas

  • Pharmacology
  • Genetics
  • Molecular Medicine

Cite this

ABCC2 rs2273697 and rs3740066 polymorphisms and resistance to antiepileptic drugs in Asia Pacific epilepsy cohorts. / Sha'Ari, Hidayati Mohd; Haerian, Batoul Sadat; Baum, Larry; Saruwatari, Junji; Tan, Hui Jan; Rafia, Mohd Hanip; Ali, Raymond Azman; Kwan, Patrick; Ishitsu, Takateru; Nakagawa, Kazuko; Lim, Kheng Seang; Mohamed, Zahurin.

In: Pharmacogenomics, Vol. 15, No. 4, 2014, p. 459-466.

Research output: Contribution to journalArticle

Sha'Ari, HM, Haerian, BS, Baum, L, Saruwatari, J, Tan, HJ, Rafia, MH, Ali, RA, Kwan, P, Ishitsu, T, Nakagawa, K, Lim, KS & Mohamed, Z 2014, 'ABCC2 rs2273697 and rs3740066 polymorphisms and resistance to antiepileptic drugs in Asia Pacific epilepsy cohorts', Pharmacogenomics, vol. 15, no. 4, pp. 459-466. https://doi.org/10.2217/pgs.13.239
Sha'Ari, Hidayati Mohd ; Haerian, Batoul Sadat ; Baum, Larry ; Saruwatari, Junji ; Tan, Hui Jan ; Rafia, Mohd Hanip ; Ali, Raymond Azman ; Kwan, Patrick ; Ishitsu, Takateru ; Nakagawa, Kazuko ; Lim, Kheng Seang ; Mohamed, Zahurin. / ABCC2 rs2273697 and rs3740066 polymorphisms and resistance to antiepileptic drugs in Asia Pacific epilepsy cohorts. In: Pharmacogenomics. 2014 ; Vol. 15, No. 4. pp. 459-466.
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