A typical (symplastic) leiomyoma of the uterus - A case report

M. A. Siti-Aishah, O. Noriah, M. N. Malini, Zainul Rashid Mohd. Razi, Srijit Das

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

A 30-year-old, nulliparous woman presented with a history of subfertility. On examination she was found to have uterine fibroid of 28 weeks size of gravid uterus and subsequently laporatomy myomectomy was performed. Multilobulated masses, with diameters ranging from 22 mm to 160 mm were found. Cut sections of the lobulated masses showed whitish whorled cut surface. One of the multilobulated masses had a cystic cavity, measuring 60×50×35 mm3. Light microscopic findings of the mass with the cystic cavity showed a well-circumscribed cellular tumour composed of cells exhibiting moderate nuclear atypia which were enlarged, nuclei with prominent chromatin clumping and were distributed in areas. Some tumour cells showed large nuclear pseudoinclusions, multinucleated or multilobated tumour giant cells, smudging and few enlarged nucleoli. Mitotic activity was 4 MFs per 10 HPFs. Occasional cells with intracytoplasmic inclusions resembling rhabdoid - like features were seen. There were no atypical mitoses or tumour necroses were noted. Diagnosis of atypical leiomyoma or symplastic leiomyoma was made. Atypical or symplastic leiomyomas are rare in the region of Malaysia and the present case discusses its incidence in younger age, its morphological features along with diagnosis and clinical outcome.

Original languageEnglish
Pages (from-to)447-450
Number of pages4
JournalClinica Terapeutica
Volume162
Issue number5
Publication statusPublished - 2011

Fingerprint

Leiomyoma
Uterus
Uterine Myomectomy
Giant Cell Tumors
Neoplasms
Malaysia
Mitosis
Infertility
Chromatin
Necrosis
Light
Incidence

Keywords

  • Atypical
  • Diagnosis
  • Leiomyoma
  • Pathology
  • Uterus

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Siti-Aishah, M. A., Noriah, O., Malini, M. N., Mohd. Razi, Z. R., & Das, S. (2011). A typical (symplastic) leiomyoma of the uterus - A case report. Clinica Terapeutica, 162(5), 447-450.

A typical (symplastic) leiomyoma of the uterus - A case report. / Siti-Aishah, M. A.; Noriah, O.; Malini, M. N.; Mohd. Razi, Zainul Rashid; Das, Srijit.

In: Clinica Terapeutica, Vol. 162, No. 5, 2011, p. 447-450.

Research output: Contribution to journalArticle

Siti-Aishah, MA, Noriah, O, Malini, MN, Mohd. Razi, ZR & Das, S 2011, 'A typical (symplastic) leiomyoma of the uterus - A case report', Clinica Terapeutica, vol. 162, no. 5, pp. 447-450.
Siti-Aishah, M. A. ; Noriah, O. ; Malini, M. N. ; Mohd. Razi, Zainul Rashid ; Das, Srijit. / A typical (symplastic) leiomyoma of the uterus - A case report. In: Clinica Terapeutica. 2011 ; Vol. 162, No. 5. pp. 447-450.
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