A systematic review of methadone maintenance therapy studies in preventing relapses in addiction: Evidence from asean countries

Nur Azlina Mohd Fahami, Ahmad Nazrun Shuid, Azman Abdullah, Isa Naina-Mohamed, Kok Yong Chin, Norazlina Mohamed, Norliana Masbah, Qodriyah Haji Mohd Saad, Yusof Kamisah, Norliza Muhammad

Research output: Contribution to journalReview article

Abstract

Background: Opioid abuse is a significant problem worldwide due to its associated healthcare and economic burdens. In ASEAN countries, methadone maintenance therapy (MMT) has been implemented for over a decade to replace forced detoxification programs. However, the overall effectiveness of MMT programs is still unclear in the region. Aims: We aimed to summarize the current evidence on the effectiveness of MMT in preventing relapses in drug addicts living in ASEAN countries. Methodology: A search through the literature for original research articles written in English and published between 1990 and 2016 was performed using PubMed, Scopus and Web of Science. Articles were screened and extracted by two independent reviewers. Results: The results showed that MMT alone or incorporation into other programs was effective in reducing concurrent illicit drug use and withdrawal from treatment across ASEAN countries. Higher methadone doses were reported to have better retention effects than those due to lower doses. Conclusion: In summary, MMT is effective in preventing relapses into addiction behaviour from occurring in patients in ASEAN countries. Health professions should adjust the methadone dosage to suit the individual requirements of patients and ensure compliance.

Original languageEnglish
Pages (from-to)15-32
Number of pages18
JournalHeroin Addiction and Related Clinical Problems
Volume21
Issue number5
Publication statusPublished - Oct 2019

Fingerprint

Methadone
Recurrence
Therapeutics
Health Occupations
Street Drugs
Patient Compliance
Drug Users
PubMed
Opioid Analgesics
Economics
Delivery of Health Care
Research

Keywords

  • Addiction
  • Harm Reduction
  • Methadone
  • Opioid
  • Relapse
  • Retention
  • Substance Abuse

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Psychiatry and Mental health

Cite this

A systematic review of methadone maintenance therapy studies in preventing relapses in addiction : Evidence from asean countries. / Mohd Fahami, Nur Azlina; Shuid, Ahmad Nazrun; Abdullah, Azman; Naina-Mohamed, Isa; Chin, Kok Yong; Mohamed, Norazlina; Masbah, Norliana; Mohd Saad, Qodriyah Haji; Kamisah, Yusof; Muhammad, Norliza.

In: Heroin Addiction and Related Clinical Problems, Vol. 21, No. 5, 10.2019, p. 15-32.

Research output: Contribution to journalReview article

Mohd Fahami, NA, Shuid, AN, Abdullah, A, Naina-Mohamed, I, Chin, KY, Mohamed, N, Masbah, N, Mohd Saad, QH, Kamisah, Y & Muhammad, N 2019, 'A systematic review of methadone maintenance therapy studies in preventing relapses in addiction: Evidence from asean countries', Heroin Addiction and Related Clinical Problems, vol. 21, no. 5, pp. 15-32.
Mohd Fahami, Nur Azlina ; Shuid, Ahmad Nazrun ; Abdullah, Azman ; Naina-Mohamed, Isa ; Chin, Kok Yong ; Mohamed, Norazlina ; Masbah, Norliana ; Mohd Saad, Qodriyah Haji ; Kamisah, Yusof ; Muhammad, Norliza. / A systematic review of methadone maintenance therapy studies in preventing relapses in addiction : Evidence from asean countries. In: Heroin Addiction and Related Clinical Problems. 2019 ; Vol. 21, No. 5. pp. 15-32.
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